{"id":"W3179962123","doi":"10.1158/1538-7445.am2021-2441","title":"Abstract 2441: Polysome profiling suggests VHL-dependent translational control in clear cell renal cell carcinoma","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Polysome; Clear cell renal cell carcinoma; Cancer research; Translational regulation; PI3K/AKT/mTOR pathway; Translational efficiency; Biology; Renal cell carcinoma; Metastasis; Kidney cancer; Tumor progression; Medicine; Gene; Cancer; Bioinformatics; Oncology; Internal medicine; Messenger RNA; Translation (biology); Genetics; Signal transduction; RNA; Ribosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007382188,0.0001306306,0.0001439614,0.0005133249,0.0001623449,0.0001869069,0.00008311378,0.0001594567,0.002508689],"category_scores_gemma":[0.0001554449,0.00005746854,0.0001071306,0.0003532463,0.0001487528,0.00009494857,0.0001160884,0.0001329838,0.000399226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178189,"about_ca_system_score_gemma":0.000108212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249687,"about_ca_topic_score_gemma":0.001451366,"domain_scores_codex":[0.9999399,0.000004972627,0.000006968316,0.00001432147,0.00002093898,0.0000128816],"domain_scores_gemma":[0.9998862,0.00002406762,0.00003143018,0.000009511429,0.00002566524,0.00002313085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00039397,0.00002024586,0.01628525,0.00007107322,0.00001454773,0.0004809108,0.00004214039,0.00008359215,0.9795375,0.00006231165,0.0001806476,0.002827782],"study_design_scores_gemma":[0.00001884786,0.000602553,0.6550274,0.00001103854,0.00005503482,0.003805466,0.0001387922,0.00107948,0.335568,0.000147698,0.003533236,0.00001255535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965882,0.0005188635,0.0006512719,0.00003753994,0.000009333635,0.00001599543,0.001456233,0.00001877245,0.0007036169],"genre_scores_gemma":[0.9944381,0.0003657187,0.0008954432,0.00002400864,0.000009677377,0.00001445597,0.002727807,0.00001122583,0.00151358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002508689,"threshold_uncertainty_score":0.008392453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06386902647025752,"score_gpt":0.358580210794377,"score_spread":0.2947111843241195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}