{"id":"W3180085542","doi":"10.1158/1538-7445.am2021-lb246","title":"Abstract LB246: E-cadherin loss drives Id2-dependent dampening of cell cycle progression and predicts increased susceptibility to CDK4/6 inhibition in lobular breast cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Breast cancer; Cancer research; Cancer; Cadherin; Cell cycle; Downregulation and upregulation; Biology; Internal medicine; Oncology; Medicine; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000748896,0.000138047,0.0002990224,0.0002364618,0.0001050265,0.00004182879,0.0000644781,0.000101275,0.001610592],"category_scores_gemma":[0.0001593379,0.0001262684,0.00005557463,0.0005295227,0.0001440636,0.0001497606,0.0001742508,0.0005921346,0.00000887481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000411046,"about_ca_system_score_gemma":0.0006882831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005000902,"about_ca_topic_score_gemma":0.002788893,"domain_scores_codex":[0.9978947,0.0001462985,0.0003725121,0.0005037176,0.0006818307,0.0004009269],"domain_scores_gemma":[0.9986044,0.0001123362,0.00007334058,0.0003185035,0.0006069232,0.0002845134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007459043,0.0003977459,0.08089091,0.0005260545,0.00001955056,0.0001935981,0.0007210338,0.0001254077,0.9123291,0.000008805857,0.0002392092,0.003802627],"study_design_scores_gemma":[0.001323249,0.0002036159,0.2922307,0.001954648,0.0000139896,0.00003684667,0.0005525037,0.0001339064,0.7032303,0.00003425143,0.0001869935,0.00009897762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996739,0.0008073927,0.00001884293,0.0009382876,0.00008879661,0.0006048398,0.0001975422,0.00002262544,0.0005826773],"genre_scores_gemma":[0.9988901,0.0003653601,0.0001355926,0.00005111189,0.0001852521,0.0001866116,0.00003898354,0.00002624918,0.000120723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2113398,"threshold_uncertainty_score":0.9993021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04310286532256443,"score_gpt":0.3925982521812948,"score_spread":0.3494953868587304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}