{"id":"W3180118157","doi":"10.1016/j.ijpharm.2021.120857","title":"Physiologically relevant dissolution conditions towards improved in vitro - in vivo relationship – A case study with enteric coated pantoprazole tablets","year":2021,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Pantoprazole; IVIVC; Bioequivalence; In vivo; Dissolution testing; In vitro; Chemistry; Chromatography; Dosage form; Phosphate buffered saline; Enteric coated; Pharmacology; Dissolution; Bioavailability; Biopharmaceutics Classification System; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005390781,0.0004548595,0.0006954475,0.0002604344,0.0004898053,0.0009050908,0.0004704458,0.001330504,0.00072069],"category_scores_gemma":[0.001286662,0.0002408899,0.0004399941,0.000313519,0.0005922148,0.0004262197,0.0004127999,0.000559465,0.000285565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003253111,"about_ca_system_score_gemma":0.0002852592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001839208,"about_ca_topic_score_gemma":0.002848391,"domain_scores_codex":[0.9993334,0.0001811886,0.00004719201,0.00009569566,0.0002856207,0.00005685554],"domain_scores_gemma":[0.9994863,0.0002534121,0.00009017866,0.00004990756,0.00008905371,0.00003115368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001246984,0.0008073632,0.004892151,0.001075773,0.00004925078,0.01556152,0.001070187,0.002964835,0.9420054,0.0004002363,0.0004224203,0.0295038],"study_design_scores_gemma":[0.0001322671,0.008781157,0.02495118,0.00009822755,0.0002959276,0.02711011,0.001654517,0.01209735,0.9115269,0.0002911089,0.01294368,0.0001176541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896947,0.002333211,0.00550161,0.0002038327,0.00002780774,0.0001951754,0.0001234901,0.00004437146,0.001875771],"genre_scores_gemma":[0.9818781,0.001999614,0.01437535,0.0000551449,0.00002164784,0.00003799169,0.00008855651,0.00002653355,0.001517021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839208,"threshold_uncertainty_score":0.003657043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176474466925645,"score_gpt":0.4439938999072757,"score_spread":0.3263464532147112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}