{"id":"W3180140028","doi":"10.1093/infdis/jiab365","title":"Are the Healthy Vulnerable? Cytomegalovirus Seropositivity in Healthy Adults Is Associated With Accelerated Epigenetic Age and Immune Dysregulation","year":2021,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Fondation de l'Hôpital Général de Montréal","keywords":"Immunology; Immune dysregulation; Medicine; Immune system; Subclinical infection; CD8; Immunosenescence; Asymptomatic; Cytomegalovirus; Immunity; Human cytomegalovirus; Internal medicine; Virus; Herpesviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380732,0.0001635622,0.0002153051,0.0003737149,0.0002385317,0.0003600488,0.0001088891,0.0003033454,0.001698871],"category_scores_gemma":[0.001001013,0.0001013204,0.0001092783,0.0003258198,0.0001997743,0.0003471351,0.0002270488,0.0002673457,0.0001528454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008026033,"about_ca_system_score_gemma":0.00009478112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007926252,"about_ca_topic_score_gemma":0.001378427,"domain_scores_codex":[0.9998989,0.00002311176,0.00001090641,0.00002751755,0.00001726365,0.00002228828],"domain_scores_gemma":[0.9995605,0.00006200802,0.0002320117,0.00002345614,0.00004147199,0.00008053683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002231138,0.00005192498,0.9916607,0.00002589991,0.00002998117,0.0002011157,0.0001965387,0.00001452963,0.00175809,0.00003736117,0.0001260133,0.005674725],"study_design_scores_gemma":[0.000002571987,0.0001361541,0.9988266,0.00001066665,0.00001556152,0.0003893228,0.0001623214,0.00004351875,0.0001321484,0.00006556463,0.0002140649,0.000001554837],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982342,0.0008343934,0.00008658188,0.0001194393,0.00001198138,0.000005537724,0.0001103018,0.000002971534,0.0005944809],"genre_scores_gemma":[0.9992908,0.0002580504,0.00008359233,0.00008197394,0.00002126659,0.000003074221,0.00006133724,6.883906e-7,0.0001990253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698871,"threshold_uncertainty_score":0.005683303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02389235669498426,"score_gpt":0.3046694862976191,"score_spread":0.2807771296026349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}