{"id":"W3180164640","doi":"10.1038/s41580-021-00389-z","title":"Molecular and cellular basis of genetically inherited skeletal muscle disorders","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke","keywords":"Duchenne muscular dystrophy; Biology; Muscle disorder; Skeletal muscle; Muscular dystrophy; ITGA7; Neuromuscular junction; Myocyte; Cell biology; Myopathy; Phenotype; Genetics; Gene; Neuroscience; Medicine; Anatomy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006419378,0.001440924,0.001914816,0.00169969,0.0002027363,0.00103319,0.001497253,0.001638407,0.003045015],"category_scores_gemma":[0.0006430406,0.0003721001,0.0004140658,0.001748451,0.0008800049,0.001128501,0.001072222,0.00263316,0.002401756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008385817,"about_ca_system_score_gemma":0.001077163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021108,"about_ca_topic_score_gemma":0.001444111,"domain_scores_codex":[0.9997635,0.00003423366,0.00003045218,0.0000408279,0.0001052759,0.00002569824],"domain_scores_gemma":[0.9997981,0.00008847394,0.000027743,0.000008229962,0.00005140794,0.00002607353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001530548,0.00007508582,0.0002039548,0.009863894,0.0001169831,0.0007616166,0.00004444948,0.001038786,0.006108241,0.01229836,0.06335961,0.9059759],"study_design_scores_gemma":[0.00003538642,0.00004272066,0.0007122753,0.001823039,0.0001240489,0.001712552,0.00003133778,0.0001203762,0.0005959895,0.005047372,0.9897376,0.0000171783],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006474819,0.9983737,0.0001868385,0.000351818,0.000232238,0.000003121118,0.00002128997,0.000008512882,0.0007576343],"genre_scores_gemma":[0.0003958976,0.9983044,0.0001932193,0.0002388792,0.0002682215,0.00000521228,0.00003430382,0.00000134035,0.0005584017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003045015,"threshold_uncertainty_score":0.01018661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009652606427028147,"score_gpt":0.2840311036923856,"score_spread":0.2743784972653575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}