{"id":"W3180197927","doi":"10.1097/pr9.0000000000000944","title":"The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex","year":2021,"lang":"en","type":"article","venue":"PAIN Reports","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Neuropathic pain; Chronic pain; Epigenetics; DNA methylation; Prefrontal cortex; Neuroscience; Neuroplasticity; Medicine; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01301663,0.0002164976,0.0004062778,0.00006988393,0.000178529,0.00002591044,0.00009171855,0.0001609117,0.0000920204],"category_scores_gemma":[0.006357417,0.0001248848,0.0001904543,0.0003741985,0.00007922977,0.00005985218,0.00006469154,0.0004690743,0.000003109647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001786849,"about_ca_system_score_gemma":0.0003606007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001639685,"about_ca_topic_score_gemma":0.0003234836,"domain_scores_codex":[0.9951083,0.002989959,0.0006761413,0.0004220955,0.0004978132,0.0003056762],"domain_scores_gemma":[0.9967077,0.001825023,0.0004324516,0.0007744724,0.0001770444,0.00008326631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658276,0.0007005581,0.01308557,0.0002446846,0.0005073635,0.007734178,0.001022153,0.0001404686,0.8110512,0.0006309269,0.001726013,0.162991],"study_design_scores_gemma":[0.004670784,0.00266413,0.1002096,0.001234108,0.001308164,0.00204069,0.004297474,0.01771424,0.785322,0.01152722,0.06794322,0.001068451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9364395,0.03594223,0.01638935,0.006616034,0.00105725,0.00234887,0.00001925844,0.0001526008,0.001034956],"genre_scores_gemma":[0.9955698,0.000600027,0.0008993416,0.0005908569,0.0001179374,0.00006921533,0.00006701796,0.00003498361,0.00205086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1619225,"threshold_uncertainty_score":0.7610881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192652342934689,"score_gpt":0.2577185183368162,"score_spread":0.2457919949074694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}