{"id":"W3180197927","doi":"10.1097/pr9.0000000000000944","title":"The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex","year":2021,"lang":"en","type":"article","venue":"PAIN Reports","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Neuropathic pain; Chronic pain; Epigenetics; DNA methylation; Prefrontal cortex; Neuroscience; Neuroplasticity; Medicine; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002347103,0.0005182439,0.0003566551,0.0008082023,0.0002060817,0.0003023288,0.0003345866,0.0003174325,0.002059667],"category_scores_gemma":[0.0001458357,0.0003336943,0.000493982,0.0003372609,0.0004001771,0.0001852551,0.0002656104,0.0007014464,0.0003260684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004258933,"about_ca_system_score_gemma":0.0004342865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002490733,"about_ca_topic_score_gemma":0.00587851,"domain_scores_codex":[0.9997585,0.00002078926,0.00001524431,0.00008063725,0.00006349877,0.00006125451],"domain_scores_gemma":[0.9997829,0.00001620212,0.0001026194,0.00002751955,0.0000242383,0.00004664481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003011918,0.00002410903,0.0002814958,0.00004683942,0.00001790703,0.00002261905,0.00001299655,0.00005205004,0.9976882,0.00004672868,0.00005163247,0.001454247],"study_design_scores_gemma":[0.00009914243,0.00122849,0.02271554,0.00002993806,0.0001085782,0.0003278418,0.00007851463,0.0008870208,0.9713256,0.0001375202,0.003049698,0.00001208796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796586,0.004480383,0.01035076,0.0003351868,0.0000908592,0.0001003807,0.002870049,0.0003980842,0.00171573],"genre_scores_gemma":[0.9841437,0.002675676,0.005999099,0.0002002446,0.00002253147,0.000187117,0.002080066,0.00009543142,0.004596034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002490733,"threshold_uncertainty_score":0.006890297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192652342934689,"score_gpt":0.2577185183368162,"score_spread":0.2457919949074694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}