{"id":"W3180287097","doi":"10.1101/2021.07.07.447795","title":"Protease activities of vaginal <i>Porphyromonas</i> species disrupt coagulation and extracellular matrix in the cervicovaginal niche","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; University of Calgary; Alberta Innovates; International Microbiome Centre, University of Calgary; National Institutes of Health; Government of Alberta","keywords":"Porphyromonas gingivalis; Biology; Microbiology; Proteases; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140269,0.0002873843,0.000174853,0.0002874643,0.0001880207,0.000422636,0.0001254531,0.0002368004,0.0007165099],"category_scores_gemma":[0.0002236557,0.00009964978,0.0002540602,0.0002142351,0.0001262689,0.0001759411,0.0002285906,0.0002250907,0.0002456862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241125,"about_ca_system_score_gemma":0.0002337192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001588262,"about_ca_topic_score_gemma":0.001099537,"domain_scores_codex":[0.9998482,0.00001802431,0.0000122211,0.00003874328,0.00003271072,0.00004997593],"domain_scores_gemma":[0.9999089,0.00001344746,0.00003437613,0.000006729501,0.0000139415,0.00002263312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008328604,0.00001265162,0.003564283,0.00004488264,0.000007306793,0.000185429,0.00003208811,0.00003504626,0.9940382,0.00003013249,0.00003866178,0.001927931],"study_design_scores_gemma":[0.00001501991,0.000380572,0.2053741,0.00005659898,0.00004993847,0.00376757,0.0004764033,0.002205115,0.7806275,0.0001712525,0.006861736,0.00001418475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954078,0.002317017,0.0008226159,0.00008069093,0.000009192991,0.00001959107,0.00038584,0.00002011107,0.0009372443],"genre_scores_gemma":[0.9954109,0.0008740951,0.002055614,0.00004418924,0.000007387629,0.00001500056,0.0006982129,0.000007567151,0.0008871186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001588262,"threshold_uncertainty_score":0.003158092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01888607140780996,"score_gpt":0.2562317926818078,"score_spread":0.2373457212739978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}