{"id":"W3180322671","doi":"10.1101/2021.07.03.451008","title":"Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria parasites","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"College of Medicine, Drexel University; Drexel University","keywords":"Plasmodium falciparum; Parasite hosting; Biology; Recombinant DNA; Enzyme; Malaria; Enzyme kinetics; Plasmodium (life cycle); Cell biology; Gene; Biochemistry; Immunology; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260434,0.0002282323,0.0001103719,0.0001209072,0.0001195766,0.0002169493,0.0001915226,0.0001781873,0.0006017057],"category_scores_gemma":[0.000153289,0.0000825787,0.000190783,0.000156001,0.0001248777,0.0001164153,0.0001318109,0.0002782388,0.0001864907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003323741,"about_ca_system_score_gemma":0.0001548177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002033137,"about_ca_topic_score_gemma":0.001561578,"domain_scores_codex":[0.9999415,0.00000840818,0.000007212462,0.00001189847,0.00001963511,0.00001126089],"domain_scores_gemma":[0.9999382,0.000009239976,0.00001464479,0.000007076372,0.00001126411,0.00001956542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130457,0.00002671344,0.0008389648,0.00003907596,0.00000893816,0.0001413203,0.00001934551,0.0003850592,0.9963459,0.0002413829,0.00007629986,0.001763959],"study_design_scores_gemma":[0.00001595404,0.0002383766,0.009894663,0.000007715901,0.00002090028,0.0006496124,0.00004620746,0.002879582,0.9799226,0.00008663831,0.006230114,0.000007555255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949596,0.0008575998,0.002492378,0.00007452157,0.00001478415,0.00001462516,0.0008739347,0.00002834828,0.0006841784],"genre_scores_gemma":[0.9911433,0.0003647304,0.003958877,0.00002989064,0.000004808666,0.000006417742,0.003174699,0.00001314248,0.001304089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033137,"threshold_uncertainty_score":0.004042566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008900411306418608,"score_gpt":0.2406524032898181,"score_spread":0.2317519919833995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}