{"id":"W3180369792","doi":"10.1007/s13311-021-01088-5","title":"Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis","year":2021,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Fonds de Recherche du Québec - Santé; National Institute of General Medical Sciences; U.S. Department of Defense","keywords":"Experimental autoimmune encephalomyelitis; Neuroprotection; Neurodegeneration; Multiple sclerosis; Medicine; Agonist; Myelin oligodendrocyte glycoprotein; Encephalomyelitis; Inflammation; Immunology; Neuroscience; Receptor; Pharmacology; Biology; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000886483,0.000223438,0.0002440566,0.00005532823,0.0000579122,0.00002711289,0.0002245169,0.0001657392,0.0001689402],"category_scores_gemma":[0.00001189195,0.0002388005,0.0001535264,0.0001998349,0.0001112315,0.00000714508,0.00008374061,0.000156094,0.000005447393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001775934,"about_ca_system_score_gemma":0.0001824269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003459677,"about_ca_topic_score_gemma":0.000004749512,"domain_scores_codex":[0.9985794,0.00009366171,0.0003895598,0.0004180541,0.0002058794,0.0003134635],"domain_scores_gemma":[0.9993042,0.00001820236,0.0001148505,0.0004137467,0.00009494954,0.00005399003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001120338,0.000429394,0.0005137417,0.000016693,0.00006245264,0.00002071076,0.0001727932,0.0003127162,0.9967511,0.0001573924,0.0002671097,0.001183892],"study_design_scores_gemma":[0.001967985,0.0003926978,0.002986311,0.00003335176,0.00002774405,0.00009642319,0.0004005689,0.0004437877,0.929491,0.00002193437,0.06382217,0.000316048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803635,0.01505567,0.002860414,0.0002409753,0.0005111584,0.0002021347,0.00002790577,0.00001970731,0.000718459],"genre_scores_gemma":[0.9955062,0.0005609241,0.001286487,0.001233808,0.0002156559,0.00002329213,0.0000822148,0.00005269994,0.001038755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06726009,"threshold_uncertainty_score":0.9738002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909608177483972,"score_gpt":0.2677871437255566,"score_spread":0.2486910619507169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}