{"id":"W3180418018","doi":"10.1038/s41586-021-03744-4","title":"Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":313,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Canadian Institutes of Health Research; Public Health Agency; Public Health Agency of Canada; AstraZeneca","keywords":"Platelet factor 4; Heparin; Antibody; Epitope; Immune system; Heparin-induced thrombocytopenia; Alanine scanning; Immunology; Platelet; Chemistry; Platelet activation; Medicine; Biochemistry; Mutagenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003644686,0.0004811629,0.001414495,0.0002834879,0.0001452666,0.00007719097,0.0003116994,0.002205804,0.001089247],"category_scores_gemma":[0.0005246063,0.0004336495,0.0003316841,0.001427367,0.00004129284,0.0002933517,0.0002338158,0.004737839,0.0003593586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586086,"about_ca_system_score_gemma":0.000600485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001548843,"about_ca_topic_score_gemma":0.000294129,"domain_scores_codex":[0.9968662,0.0001707813,0.0007188803,0.0008956977,0.000544908,0.0008035291],"domain_scores_gemma":[0.9979725,0.0001453827,0.0001402241,0.001127898,0.0003309379,0.0002829975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000839329,0.0006315549,0.06614767,0.000155431,0.0002141677,0.001216871,0.0003956508,0.00000231275,0.9273273,0.002011788,0.00033391,0.001479361],"study_design_scores_gemma":[0.003308413,0.0001907067,0.7508441,0.0003982556,0.0001754842,0.0004726915,0.0003180657,0.00004945383,0.2398363,0.0005570679,0.003419575,0.0004299222],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735236,0.002970553,0.00001665261,0.00603435,0.001158594,0.0005301917,0.0000109172,0.0001783081,0.01557686],"genre_scores_gemma":[0.9949172,0.0004784215,0.001018507,0.002225136,0.0003912759,0.00002085805,0.0002885031,0.00009034532,0.0005698024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6874911,"threshold_uncertainty_score":0.9998239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861043298773217,"score_gpt":0.3349322333225607,"score_spread":0.3163218003348285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}