{"id":"W3180418018","doi":"10.1038/s41586-021-03744-4","title":"Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":313,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Canadian Institutes of Health Research; Public Health Agency; Public Health Agency of Canada; AstraZeneca","keywords":"Platelet factor 4; Heparin; Antibody; Epitope; Immune system; Heparin-induced thrombocytopenia; Alanine scanning; Immunology; Platelet; Chemistry; Platelet activation; Medicine; Biochemistry; Mutagenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002974538,0.0001976818,0.0001206243,0.0002212193,0.0001052033,0.0002465519,0.0001881957,0.0005581117,0.002204946],"category_scores_gemma":[0.000386437,0.00009208113,0.0001142661,0.0000762994,0.000117592,0.0002085865,0.0001388403,0.0004383581,0.0001993321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374545,"about_ca_system_score_gemma":0.0001000012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001182775,"about_ca_topic_score_gemma":0.0001006642,"domain_scores_codex":[0.9999135,0.00004184808,0.000005296865,0.000005972523,0.00001228622,0.00002123488],"domain_scores_gemma":[0.9999094,0.00003964541,0.00002082544,0.000006901387,0.000009314434,0.00001390817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00522931,0.001831763,0.01872135,0.0008663135,0.0001624802,0.006310056,0.0002421564,0.004458667,0.7329623,0.02698026,0.004040986,0.1981943],"study_design_scores_gemma":[0.002892832,0.02723905,0.1552582,0.0006868324,0.0005729368,0.06354814,0.0005583892,0.03867301,0.6039954,0.02741496,0.0790998,0.00006043214],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774618,0.0112698,0.002659068,0.0007259788,0.0001461479,0.00004440455,0.00004092701,0.00002536753,0.007626612],"genre_scores_gemma":[0.9972862,0.001410173,0.0002964884,0.0001131916,0.00005433672,0.00000958482,0.00003472675,0.000002212725,0.0007931397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002204946,"threshold_uncertainty_score":0.007376313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861043298773217,"score_gpt":0.3349322333225607,"score_spread":0.3163218003348285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}