{"id":"W3180418576","doi":"10.1158/1538-7445.am2021-lb034","title":"Abstract LB034: Analysis of PD-L1 IHC tests using NIST SRM 1934-traceable reference materials: A new paradigm for development of predictive IHC biomarkers","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Saskatchewan Health Authority","funders":"","keywords":"Immunohistochemistry; Gold standard (test); Detection limit; NIST; Chemistry; Medicine; Pathology; Internal medicine; Computer science; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0163038,0.0007427244,0.0004814301,0.003170516,0.000424412,0.001855913,0.001576957,0.0009849411,0.002430275],"category_scores_gemma":[0.0133901,0.000402444,0.0004005796,0.001508527,0.001265904,0.001047368,0.001299213,0.0007142485,0.001300975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001887539,"about_ca_system_score_gemma":0.001386881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003927649,"about_ca_topic_score_gemma":0.004611837,"domain_scores_codex":[0.9867006,0.004280133,0.001041292,0.001645443,0.006058949,0.00027354],"domain_scores_gemma":[0.9918146,0.002262281,0.001644997,0.0009594123,0.003109053,0.0002096777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009741011,0.0003348367,0.1907366,0.0006276159,0.0002001771,0.0003312139,0.0004851457,0.003474376,0.5735308,0.00306947,0.007006705,0.219229],"study_design_scores_gemma":[0.00008630952,0.001489382,0.1419395,0.0002376219,0.0002525173,0.0019297,0.000615589,0.02331062,0.792379,0.002571621,0.03508354,0.0001046035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6535835,0.005963699,0.301377,0.002379926,0.0002045281,0.0009936608,0.00300162,0.005278186,0.02721781],"genre_scores_gemma":[0.8327723,0.0005503282,0.1586439,0.001041446,0.00006120376,0.0002825583,0.002446765,0.0002532977,0.00394825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0163038,"threshold_uncertainty_score":0.08622372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2192037821505408,"score_gpt":0.4628279812499276,"score_spread":0.2436241990993868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}