{"id":"W3180458932","doi":"10.1016/j.jcyt.2021.05.007","title":"Development of a B-cell maturation antigen-specific T-cell antigen coupler receptor for multiple myeloma","year":2021,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; McMaster University Medical Centre","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Receptor; T-cell receptor; Antigen; Cell biology; T cell; Chimeric antigen receptor; Cancer research; Biology; Monoclonal antibody; Immunology; Chemistry; Antibody; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003556425,0.0002270856,0.0004450484,0.0001429625,0.0001310915,0.00003775211,0.0001427635,0.0001644961,0.004638338],"category_scores_gemma":[0.000022832,0.0002134067,0.000191256,0.0003579567,0.00007094543,0.00006949517,0.00002792014,0.0001658036,0.0001018871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001522994,"about_ca_system_score_gemma":0.0005316709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004049895,"about_ca_topic_score_gemma":0.00001504505,"domain_scores_codex":[0.9980984,0.00005146194,0.0005076658,0.0004544288,0.0004765658,0.0004114895],"domain_scores_gemma":[0.9985622,0.0001479564,0.000141635,0.0005046443,0.0004975664,0.0001459888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001567594,0.000583652,0.002504062,0.0001381342,0.000088026,0.000009474225,0.00192166,0.000002142297,0.9461675,0.00001687378,0.003750494,0.04325033],"study_design_scores_gemma":[0.003720556,0.0001287354,0.004981136,0.00004141277,0.000003141309,0.000005757552,0.000288515,0.0001621025,0.611981,0.000007596452,0.3785421,0.0001379377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867705,0.002892493,0.00677517,0.0002908481,0.0002663941,0.001229067,0.00002965488,0.00006160788,0.001684303],"genre_scores_gemma":[0.7818779,0.008170132,0.1806247,0.000532248,0.0006201675,0.0002388884,0.0006251734,0.0002152377,0.02709557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3747916,"threshold_uncertainty_score":0.9962716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379794141137245,"score_gpt":0.3032591268256329,"score_spread":0.2594611854142605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}