{"id":"W3180549194","doi":"10.1158/1538-7445.am2021-2407","title":"Abstract 2407: Serine and threonine phosphorylation marks proteins for degradation by ClpXP","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Phosphorylation; Biochemistry; Biology; Serine; Protease; Threonine; Phosphatase; Casein; Arginine; Amino acid; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640024,0.0005120321,0.0003726025,0.0001276874,0.0001173103,0.0003031187,0.0002273776,0.0003262945,0.002867673],"category_scores_gemma":[0.0001785946,0.000124773,0.0002579587,0.0001810469,0.0001695318,0.0002328311,0.0001825399,0.0006539153,0.001103446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554612,"about_ca_system_score_gemma":0.0001296223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002447195,"about_ca_topic_score_gemma":0.0001702025,"domain_scores_codex":[0.9998158,0.00002997997,0.00001683113,0.00004641113,0.00005530106,0.00003579554],"domain_scores_gemma":[0.9998732,0.00002752529,0.00003524223,0.00001501628,0.0000220666,0.00002695262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009347378,0.00001126326,0.00006335558,0.00004438804,0.00000326291,0.00004874979,0.000003204512,0.00001472547,0.9993314,0.00002213282,0.00003307292,0.0003311245],"study_design_scores_gemma":[0.00000914769,0.0001245212,0.002731314,0.000006312246,0.000004173107,0.0003236386,0.000009345013,0.0003059596,0.995558,0.00002460628,0.0009003427,0.000002716278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867443,0.005022892,0.004549827,0.0002179831,0.00008881429,0.00003946895,0.001148153,0.000124023,0.002064584],"genre_scores_gemma":[0.9872659,0.001364707,0.003938139,0.0001605842,0.0000348523,0.0000380183,0.002146094,0.00005398694,0.004997694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002867673,"threshold_uncertainty_score":0.009593308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04102618336899519,"score_gpt":0.3913401635929476,"score_spread":0.3503139802239524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}