{"id":"W3180575562","doi":"10.1158/1538-7445.am2021-1427","title":"Abstract 1427: Sensitizing HL60 acute myeloid leukemia cells to decitabine with pterostilbene","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Decitabine; Myeloid leukemia; Pterostilbene; HL60; Leukemia; Medicine; Cancer research; DNA demethylation; Azacitidine; Demethylating agent; Hypomethylating agent; Cell culture; Pharmacology; Cell growth; DNA methylation; Gene expression; Chemistry; Biology; Internal medicine; Gene; Biochemistry; Resveratrol; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053276,0.000294466,0.0004222798,0.000152721,0.0001208024,0.0002131465,0.0001350158,0.0002459722,0.002902036],"category_scores_gemma":[0.00007950346,0.0000993081,0.0002450529,0.000201957,0.000139482,0.0001111607,0.0001650848,0.0004219168,0.0008065238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984766,"about_ca_system_score_gemma":0.000162755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005443518,"about_ca_topic_score_gemma":0.0007982765,"domain_scores_codex":[0.9998449,0.00002058141,0.00001856353,0.00002985729,0.00005629257,0.00002976052],"domain_scores_gemma":[0.9999493,0.00001030141,0.000008944311,0.000007614583,0.00001024629,0.00001356276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009648037,0.00003919198,0.00006620138,0.00005317903,0.00000280056,0.00002008868,0.00001042471,0.0000314702,0.9982669,0.00001993318,0.00007306074,0.001320119],"study_design_scores_gemma":[0.00001798511,0.0005787564,0.002044155,0.000006530358,0.000008389409,0.00007391229,0.00001414032,0.000160644,0.9946083,0.00001312196,0.002471293,0.000002672929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837185,0.004349238,0.003011198,0.0002625446,0.0001629766,0.0001822123,0.002348416,0.0002058124,0.005759068],"genre_scores_gemma":[0.9815267,0.002556724,0.003517138,0.00017518,0.00004194185,0.0001804484,0.003383117,0.00003357214,0.008585335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002902036,"threshold_uncertainty_score":0.009708285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03594536641624305,"score_gpt":0.3590123343916237,"score_spread":0.3230669679753807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}