{"id":"W3180649351","doi":"10.3390/cancers13143512","title":"VLA-4 Induces Chemoresistance of T Cell Acute Lymphoblastic Leukemia Cells via PYK2-Mediated Drug Efflux","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Doxorubicin; Fibronectin; Jurkat cells; Cancer research; Cell adhesion; Focal adhesion; Cell biology; Stromal cell; Apoptosis; Chemistry; Biology; Cell; Immunology; Signal transduction; Immune system; T cell; Chemotherapy; Extracellular matrix; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009365726,0.0003203243,0.0003167315,0.0002092178,0.0001722618,0.0003240275,0.0001627404,0.0002041048,0.001529421],"category_scores_gemma":[0.00008957302,0.0001277859,0.0003475382,0.0002136862,0.0001536482,0.000169735,0.0002106724,0.000688059,0.0002779382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768433,"about_ca_system_score_gemma":0.0002262999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005332327,"about_ca_topic_score_gemma":0.0005836964,"domain_scores_codex":[0.9998589,0.0000313668,0.00001198115,0.00001546347,0.00002552163,0.00005677486],"domain_scores_gemma":[0.9999645,0.000006808815,0.000008835849,0.000006564693,0.000003710637,0.000009691998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000317688,0.0001373265,0.0004157542,0.00006221528,0.00001497523,0.0000912433,0.00001674315,0.0001683702,0.9967009,0.0001138539,0.00008468842,0.001876144],"study_design_scores_gemma":[0.00009424515,0.0008454355,0.007582766,0.000007317772,0.00003603699,0.0004085597,0.00003843244,0.00194039,0.9866867,0.00007453514,0.002279662,0.000006066715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970533,0.001069363,0.0007153605,0.00008960552,0.00002108348,0.0000245777,0.0001750323,0.00004253062,0.0008092888],"genre_scores_gemma":[0.9972389,0.0005824977,0.0005303894,0.00004218952,0.000006725557,0.00004516736,0.0004267747,0.000007392365,0.001119896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529421,"threshold_uncertainty_score":0.005116463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009960528111909313,"score_gpt":0.2607790000675818,"score_spread":0.2508184719556724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}