{"id":"W3180672292","doi":"10.1172/jci.insight.143385","title":"ACTH treatment promotes murine cardiac allograft acceptance","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; International Society for Heart and Lung Transplantation; Wellcome Trust; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Mallinckrodt Pharmaceuticals; Brigham and Women's Hospital; National Institute on Aging; Bristol-Myers Squibb","keywords":"IL-2 receptor; Medicine; Heart transplantation; Melanocortin; Adrenocorticotropic hormone; Transplantation; Immunology; Receptor; Internal medicine; Endocrinology; Hormone; T cell; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002681413,0.0004803654,0.0004059976,0.0004303289,0.0001857861,0.0003451494,0.000238283,0.0004687162,0.002365885],"category_scores_gemma":[0.0001759342,0.0001747507,0.0003836821,0.0001253978,0.0002430541,0.0002189628,0.0002864425,0.001753307,0.0006048259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765184,"about_ca_system_score_gemma":0.0001805472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003236468,"about_ca_topic_score_gemma":0.0005297072,"domain_scores_codex":[0.9996274,0.00007790162,0.00003249631,0.00007411707,0.0001001262,0.00008794697],"domain_scores_gemma":[0.9996543,0.0000740129,0.00007061053,0.00004248356,0.00002462134,0.0001338218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006090056,0.000442717,0.0001502516,0.00005069537,0.000006894066,0.00008162082,0.00005454142,0.0001228395,0.9957492,0.000148498,0.0001158508,0.002467792],"study_design_scores_gemma":[0.0002369935,0.006644045,0.004202275,0.00003605875,0.00003536158,0.0003026458,0.00007200483,0.002340272,0.980996,0.0002392106,0.004878251,0.00001685682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988917,0.002347074,0.00287403,0.0003049299,0.0003169348,0.0000912076,0.0005241014,0.0002736488,0.004351107],"genre_scores_gemma":[0.9918401,0.0008319825,0.001860486,0.0001509129,0.00008935865,0.00007893871,0.0003262437,0.00004771825,0.004774146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002365885,"threshold_uncertainty_score":0.007914662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548882558899863,"score_gpt":0.2407625306823608,"score_spread":0.2252737050933622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}