{"id":"W3180697236","doi":"10.1158/1538-7445.am2021-1401","title":"Abstract 1401: MYC mediates retinoic acid resistance by suppressing cellular retinoic acid-binding protein (CRABP2) transcription in HER2-enriched breast cancers","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cancer research; Retinoic acid; Breast cancer; Transcription factor; Acute promyelocytic leukemia; Promyelocytic leukemia protein; Biology; Gene; Medicine; Cancer; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001316585,0.0003751253,0.0003858285,0.0001634615,0.0003553827,0.0002150415,0.0006392036,0.0005048313,0.0003795535],"category_scores_gemma":[0.0003338807,0.0003955041,0.0001456844,0.0008553434,0.0004212357,0.0000413784,0.00016368,0.001011435,0.00001982742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006620922,"about_ca_system_score_gemma":0.001588029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002825838,"about_ca_topic_score_gemma":0.0007613488,"domain_scores_codex":[0.9956199,0.0004972258,0.0005726796,0.001217411,0.0009184545,0.001174356],"domain_scores_gemma":[0.9982994,0.00003687026,0.0001578142,0.0007073126,0.0005406907,0.0002579611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000389053,0.00007319544,0.0009464814,0.0006233776,0.00004587019,0.0001110022,0.0002535546,0.00002265487,0.9920741,0.00001734798,0.004262373,0.001181006],"study_design_scores_gemma":[0.001013587,0.00006434112,0.0003315662,0.0005065374,0.00001364617,0.00001253714,0.00068697,0.00001202281,0.9835107,0.0001266271,0.01328163,0.0004397922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958334,0.0376437,0.0001190464,0.0008654058,0.0002183143,0.0005190231,0.0001434157,0.00003370109,0.002123397],"genre_scores_gemma":[0.9884719,0.003877328,0.0002238649,0.00005715974,0.000450006,0.0004889479,0.0005681411,0.00009629851,0.005766362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03376638,"threshold_uncertainty_score":0.9998497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0220402658785659,"score_gpt":0.3095192466543812,"score_spread":0.2874789807758154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}