{"id":"W3180697236","doi":"10.1158/1538-7445.am2021-1401","title":"Abstract 1401: MYC mediates retinoic acid resistance by suppressing cellular retinoic acid-binding protein (CRABP2) transcription in HER2-enriched breast cancers","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cancer research; Retinoic acid; Breast cancer; Transcription factor; Acute promyelocytic leukemia; Promyelocytic leukemia protein; Biology; Gene; Medicine; Cancer; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352803,0.0003345378,0.0002309383,0.0002107538,0.0002005912,0.0003063634,0.0002563845,0.000358316,0.004932071],"category_scores_gemma":[0.0001120096,0.0001298518,0.0002372133,0.0001309718,0.0002219901,0.0001342713,0.0002242416,0.0004636587,0.00169401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004298804,"about_ca_system_score_gemma":0.0002210721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003251694,"about_ca_topic_score_gemma":0.0003642965,"domain_scores_codex":[0.9998858,0.00001568938,0.000009024737,0.00002605826,0.0000353139,0.00002812668],"domain_scores_gemma":[0.999915,0.00001273071,0.00002365471,0.000008836204,0.00001088505,0.00002901649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001366763,0.00002379588,0.0002957674,0.00005193505,0.000004254105,0.0001059386,0.000007900951,0.00006591486,0.9980375,0.0001881764,0.0002338465,0.0008482265],"study_design_scores_gemma":[0.00005712108,0.000347633,0.01021175,0.00001375513,0.00001573512,0.0008709207,0.00004409995,0.001077468,0.9805768,0.000176669,0.006602423,0.000005525375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787774,0.005089671,0.004803275,0.0007357966,0.0001351526,0.00007953464,0.002145823,0.0003719933,0.007861379],"genre_scores_gemma":[0.9818339,0.001461736,0.001983027,0.0002241752,0.00004537241,0.0001076743,0.002321835,0.00005397859,0.01196826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004932071,"threshold_uncertainty_score":0.01649946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0220402658785659,"score_gpt":0.3095192466543812,"score_spread":0.2874789807758154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}