{"id":"W3180740192","doi":"10.1038/s41422-021-00525-6","title":"Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs","year":2021,"lang":"en","type":"letter","venue":"Cell Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; ShanghaiTech University; Vetenskapsrådet; Novo Nordisk; Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning; Karolinska Institutet; Svenska Sällskapet för Medicinsk Forskning; Novo Nordisk Fonden; National Natural Science Foundation of China; Stiftelsen Lars Hiertas Minne; Cancerfonden; Deutsche Forschungsgemeinschaft; University of Southern California","keywords":"Heterotrimeric G protein; Frizzled; Cell biology; Chemistry; Biology; Signal transduction; G protein; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001440507,0.000294178,0.0004699962,0.0002555881,0.0001038133,0.00004240348,0.0005125882,0.0008413441,0.0001867471],"category_scores_gemma":[0.00003263477,0.0002656041,0.0001088249,0.0003247152,0.0005595915,0.000003141968,0.0003486744,0.001810753,0.000004921136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007044054,"about_ca_system_score_gemma":0.0005832722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001890727,"about_ca_topic_score_gemma":0.0003767831,"domain_scores_codex":[0.997539,0.0004015113,0.0002862807,0.0007142836,0.0004602942,0.0005986745],"domain_scores_gemma":[0.9986248,0.00004875675,0.0001356709,0.0006516179,0.0004760543,0.00006308993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009096086,0.0000581184,0.0002509688,0.000305907,0.00007121162,0.0001659443,0.00008920567,0.000009012991,0.8608427,0.000006655665,0.1379238,0.0001854656],"study_design_scores_gemma":[0.0009810545,0.0004791118,0.0007059398,0.000109319,0.00002120416,0.00002043239,0.0002150308,0.000004109954,0.699948,0.00002825367,0.2971386,0.0003489812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886918,0.0008383114,0.0001129241,0.002887259,0.00006898131,0.0009509936,0.0006283232,0.000006933195,0.005814473],"genre_scores_gemma":[0.9800472,0.000231904,0.0004459126,0.00965195,0.0006657413,0.00003516082,0.005634323,0.00008048019,0.003207329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1608948,"threshold_uncertainty_score":0.9999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04857789463447519,"score_gpt":0.3294344726626266,"score_spread":0.2808565780281514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}