{"id":"W3180740192","doi":"10.1038/s41422-021-00525-6","title":"Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs","year":2021,"lang":"en","type":"letter","venue":"Cell Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; ShanghaiTech University; Vetenskapsrådet; Novo Nordisk; Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning; Karolinska Institutet; Svenska Sällskapet för Medicinsk Forskning; Novo Nordisk Fonden; National Natural Science Foundation of China; Stiftelsen Lars Hiertas Minne; Cancerfonden; Deutsche Forschungsgemeinschaft; University of Southern California","keywords":"Heterotrimeric G protein; Frizzled; Cell biology; Chemistry; Biology; Signal transduction; G protein; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130596,0.0004140976,0.0003153374,0.0002563212,0.0009161661,0.0005790021,0.001397736,0.002244615,0.003989168],"category_scores_gemma":[0.0006456222,0.0003670648,0.000442926,0.0001774251,0.0005603856,0.0006299795,0.0003141839,0.002783651,0.001509457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00185316,"about_ca_system_score_gemma":0.0003184276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005570197,"about_ca_topic_score_gemma":0.006266327,"domain_scores_codex":[0.9999306,0.000005880494,0.000005029383,0.00001406483,0.00002515675,0.00001921737],"domain_scores_gemma":[0.9997421,0.0001025508,0.0000276906,0.00002778771,0.00004680408,0.00005308536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002573508,0.0004741009,0.003739827,0.0005727713,0.0002804656,0.01387777,0.0004524249,0.002844536,0.830429,0.007156703,0.1276306,0.009968454],"study_design_scores_gemma":[0.001278401,0.0006956995,0.05813753,0.0002134658,0.0005161834,0.01490719,0.001372009,0.05070212,0.6267136,0.00654806,0.2387049,0.0002109396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.801425,0.01673563,0.00896947,0.1313003,0.01070329,0.00008592311,0.003710976,0.0008175995,0.02625187],"genre_scores_gemma":[0.933091,0.006545147,0.008544744,0.0144286,0.00156094,0.0000950611,0.005943459,0.0002292842,0.02956167],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005570197,"threshold_uncertainty_score":0.01344562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04857789463447519,"score_gpt":0.3294344726626266,"score_spread":0.2808565780281514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}