{"id":"W3180743587","doi":"10.21203/rs.3.rs-77798/v1","title":"Opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Medical Research Council; National Institutes of Health; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Gene; Evolutionary biology; Biology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002886345,0.0001929249,0.0003136099,0.001136079,0.0005277303,0.0004618774,0.0001831106,0.0004109075,0.002668255],"category_scores_gemma":[0.0007177712,0.000135768,0.0002246557,0.0006750614,0.000652411,0.0002532754,0.0004640593,0.0001905069,0.0001905381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000347247,"about_ca_system_score_gemma":0.0002186828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003508151,"about_ca_topic_score_gemma":0.008327186,"domain_scores_codex":[0.9997084,0.0000454306,0.00001639026,0.0001268282,0.00005060393,0.00005231997],"domain_scores_gemma":[0.9998179,0.00007605856,0.00004015584,0.00001568567,0.00002223126,0.00002789893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001757244,0.00004510341,0.5220804,0.0002872293,0.0006147398,0.003981858,0.006296169,0.0009394815,0.4059511,0.003360414,0.0004860579,0.05420021],"study_design_scores_gemma":[0.00002573745,0.00008818344,0.9847751,0.00005620343,0.00009066117,0.003338904,0.001272009,0.0005051647,0.006191099,0.00102651,0.002603966,0.00002654771],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984607,0.0003617012,0.0002248497,0.00003542509,0.000003002252,0.000002480175,0.0001709679,0.000005755806,0.0007351914],"genre_scores_gemma":[0.9990745,0.0001592602,0.000267886,0.0000258447,0.000005049856,0.000004340819,0.0001829765,0.000005985814,0.0002741504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003508151,"threshold_uncertainty_score":0.008926213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2923644775349792,"score_gpt":0.4498448108017623,"score_spread":0.1574803332667831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}