{"id":"W3180853053","doi":"10.1186/s13148-021-01126-1","title":"The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes","year":2021,"lang":"en","type":"review","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge; University of Manitoba; CancerCare Manitoba","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Comisión Nacional de Investigación Científica y Tecnológica; CancerCare Manitoba Foundation; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; University of Manitoba; Natural Sciences and Engineering Research Council of Canada","keywords":"Epigenetics; H3K4me3; Human genetics; Biology; Genetics; Gene; Computational biology; Epigenomics; Evolutionary biology; DNA methylation; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002093846,0.0008419809,0.002304998,0.000103434,0.0003051984,0.0001164429,0.001327277,0.001668624,0.00006127951],"category_scores_gemma":[0.001520775,0.0006555107,0.002232255,0.0004321002,0.0009100222,0.000002722346,0.0008758934,0.0006740947,0.00006089448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004303951,"about_ca_system_score_gemma":0.001523399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001758705,"about_ca_topic_score_gemma":0.0001060544,"domain_scores_codex":[0.9921836,0.001800924,0.003265509,0.001393495,0.0005867749,0.0007696743],"domain_scores_gemma":[0.9942527,0.0009834371,0.001550177,0.002380972,0.0004736049,0.0003590777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000294715,0.0002343954,0.00007858552,0.001257292,0.0006746827,0.00001571112,0.00001035416,0.00004309361,0.0008500943,0.00008557988,0.0002271991,0.9964935],"study_design_scores_gemma":[0.0004092099,0.0006376722,0.00007997172,0.001120496,0.0008892003,0.00001473107,0.00002323369,0.00003566061,0.0006461932,0.0007120397,0.9947199,0.0007117561],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004690021,0.98852,0.00347442,0.00004507456,0.001670166,0.0009819173,0.0001389865,0.00001679884,0.000462616],"genre_scores_gemma":[0.0003690141,0.9926872,0.00318537,0.00005237984,0.0009993832,0.0001082988,0.0007408608,0.0001924331,0.001665021],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9957818,"threshold_uncertainty_score":0.9996274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03670675112389615,"score_gpt":0.4143564149759556,"score_spread":0.3776496638520594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}