{"id":"W3180853053","doi":"10.1186/s13148-021-01126-1","title":"The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes","year":2021,"lang":"en","type":"review","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge; University of Manitoba; CancerCare Manitoba","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Comisión Nacional de Investigación Científica y Tecnológica; CancerCare Manitoba Foundation; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; University of Manitoba; Natural Sciences and Engineering Research Council of Canada","keywords":"Epigenetics; H3K4me3; Human genetics; Biology; Genetics; Gene; Computational biology; Epigenomics; Evolutionary biology; DNA methylation; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000269043,0.0005365691,0.0007521908,0.001241229,0.0001892499,0.0007858478,0.0004191373,0.0005028028,0.002830844],"category_scores_gemma":[0.0003154742,0.0001717878,0.0002783636,0.001306639,0.0004700123,0.0007520528,0.0004523812,0.0007504073,0.001893761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006162731,"about_ca_system_score_gemma":0.000688954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008910045,"about_ca_topic_score_gemma":0.00116689,"domain_scores_codex":[0.9998723,0.00001788563,0.00001690792,0.00003730182,0.00004185997,0.00001371139],"domain_scores_gemma":[0.999884,0.00004312977,0.00002626274,0.000004155235,0.00003023717,0.0000122259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001577104,0.00004407385,0.001161844,0.0103408,0.00009533417,0.0006067972,0.0001722613,0.0005656306,0.03369381,0.006166765,0.02162624,0.9253687],"study_design_scores_gemma":[0.000008646894,0.00009498571,0.004273687,0.0008181838,0.0001028401,0.003269632,0.000104281,0.0002273265,0.009293013,0.003799674,0.9779775,0.00003028523],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001597316,0.991804,0.001573773,0.0006567594,0.0002239535,0.000008688372,0.0001315271,0.00004432082,0.003959682],"genre_scores_gemma":[0.00881623,0.9852843,0.001157626,0.0003285831,0.0003271395,0.00001455722,0.000255791,0.00000786367,0.003807919],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002830844,"threshold_uncertainty_score":0.009470105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03670675112389615,"score_gpt":0.4143564149759556,"score_spread":0.3776496638520594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}