{"id":"W3180942646","doi":"10.1158/1538-7445.am2021-885","title":"Abstract 885: A risk prediction tool for individuals with a family history of breast, ovarian, or pancreatic cancer: BRCAPANCPRO","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pancreatic cancer; Ovarian cancer; Breast cancer; Family history; Oncology; Medicine; Internal medicine; Cancer; Genetic testing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002231807,0.0008133553,0.0006415818,0.002177921,0.0002852546,0.0009025709,0.0009311945,0.0007765368,0.006813944],"category_scores_gemma":[0.01174119,0.000275615,0.0008351078,0.0007834063,0.0001176232,0.0004886306,0.0007761772,0.0006708238,0.00151334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004309952,"about_ca_system_score_gemma":0.0007270177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007847093,"about_ca_topic_score_gemma":0.006792399,"domain_scores_codex":[0.9992118,0.000322531,0.00005724806,0.0002185555,0.0001550298,0.00003474284],"domain_scores_gemma":[0.9953561,0.003165642,0.0005878088,0.0002832354,0.0003770748,0.0002300295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00227567,0.0005742974,0.6615337,0.0003712858,0.001005913,0.0009328054,0.0001663163,0.08465526,0.001343613,0.001879014,0.0518202,0.193442],"study_design_scores_gemma":[0.0003733427,0.0005443443,0.1315259,0.0002067432,0.0005596887,0.002428195,0.0001451248,0.8395663,0.002456264,0.005857138,0.01623617,0.0001006901],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.767617,0.00291101,0.142678,0.004866801,0.0002075501,0.0004613623,0.05689273,0.01056152,0.01380405],"genre_scores_gemma":[0.9302722,0.0005008532,0.04464293,0.000628602,0.0001111057,0.0002198826,0.02101029,0.0002293845,0.002384751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007847093,"threshold_uncertainty_score":0.0227949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04772035852296019,"score_gpt":0.3516867823459148,"score_spread":0.3039664238229546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}