{"id":"W3180955020","doi":"10.1158/1538-7445.am2021-1932","title":"Abstract 1932: Talazoparib interacts with oncolytic reovirus to enhance death-inducing signaling complex (DISC)-mediated apoptosis and immune response","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Cancer research; Paracrine signalling; Immune system; PARP1; Apoptosis; Medicine; Oncolytic adenovirus; Chemokine; Autocrine signalling; Cytokine; PARP inhibitor; In vivo; Immunosurveillance; Poly ADP ribose polymerase; Immunology; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172874,0.0003624083,0.0002966973,0.0001767214,0.0001259301,0.0002457429,0.000171523,0.0002495002,0.002656939],"category_scores_gemma":[0.00007064689,0.00009145169,0.0003156604,0.0001454639,0.0001122449,0.0001262431,0.0001417037,0.0004919241,0.0006762097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004421049,"about_ca_system_score_gemma":0.0001615369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005088018,"about_ca_topic_score_gemma":0.0006202585,"domain_scores_codex":[0.9998983,0.0000161853,0.000006335898,0.0000157118,0.00002580031,0.00003770092],"domain_scores_gemma":[0.999977,0.000004595972,0.000005343613,0.000002438253,0.000003341773,0.000007281229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003981534,0.00007948986,0.0001053368,0.00005025397,0.00001316615,0.0000497992,0.00000813491,0.0001952371,0.9968971,0.00008989977,0.0001975848,0.001915892],"study_design_scores_gemma":[0.00007861647,0.0006375877,0.000938448,0.00000359306,0.00001577296,0.0001762875,0.000008684975,0.001040553,0.9947519,0.00002635131,0.002318329,0.000003898382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903935,0.002249907,0.002965224,0.0001736572,0.00005835763,0.00007847734,0.001045828,0.0001444431,0.002890591],"genre_scores_gemma":[0.9944137,0.0005717736,0.001388854,0.00008618432,0.00001045989,0.0000424594,0.001201096,0.00001478291,0.002270745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002656939,"threshold_uncertainty_score":0.008888364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06543128242452048,"score_gpt":0.4147516637815538,"score_spread":0.3493203813570332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}