{"id":"W3180960802","doi":"10.1158/1538-7445.am2021-563","title":"Abstract 563: cfDNA-based analysis of minimal residual disease and T-cell receptor clonality as predictors of relapse in stage 3 NSCLC treated with chemoradiotherapy and durvalumab","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Durvalumab; Oncology; Medicine; Internal medicine; Immunotherapy; Stage (stratigraphy); T-cell receptor; Minimal residual disease; Chemoradiotherapy; Adjuvant; Cancer; Immunology; T cell; Immune system; Nivolumab; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003658014,0.000135649,0.0002772467,0.0003491204,0.0002107594,0.0003526823,0.0002414003,0.0003062261,0.001382816],"category_scores_gemma":[0.000871675,0.00008359794,0.0002527888,0.0003069288,0.0001279876,0.0001354921,0.0001620681,0.0002818862,0.0002031597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398951,"about_ca_system_score_gemma":0.000219023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00287124,"about_ca_topic_score_gemma":0.004868071,"domain_scores_codex":[0.9998379,0.00002481342,0.00001781063,0.00005611877,0.00004296932,0.00002040313],"domain_scores_gemma":[0.9995993,0.0001198174,0.0001090185,0.00003242271,0.00008733038,0.00005206278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002251939,0.00008462882,0.9187389,0.00007331462,0.0001309095,0.0001328897,0.00009193049,0.0007676771,0.05488059,0.00004781688,0.0006928535,0.02210655],"study_design_scores_gemma":[0.00003645095,0.0003891336,0.981454,0.00001286231,0.0001124639,0.0005688974,0.00006890811,0.003389149,0.01295183,0.000062406,0.0009429062,0.00001098427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982793,0.0003248161,0.0003027842,0.00004278605,0.000007322756,0.00001383657,0.0007394198,0.00001576084,0.0002738729],"genre_scores_gemma":[0.9977939,0.00006243426,0.0007093527,0.00005143339,0.000008356416,0.00001733952,0.001066145,0.000004270315,0.0002867365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00287124,"threshold_uncertainty_score":0.005708992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02057592005323143,"score_gpt":0.3268703039137077,"score_spread":0.3062943838604762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}