{"id":"W3181008393","doi":"10.21203/rs.3.rs-617615/v1","title":"The RIO Trial: Rationale, Design, And The Role of Community Involvement In A Randomised Placebo-Controlled Trial of Antiretroviral Therapy Plus Dual Long-Acting HIV-Specific Broadly Neutralising Antibodies (bNAbs) In Participants Diagnosed With Recent HIV Infection - Study Protocol For A Two-Stage Randomised Phase II Trial","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Israel Cancer Research Fund; Medical Research Council; National Institute for Health and Care Research; Gilead Sciences; Bill and Melinda Gates Foundation","keywords":"Medicine; Human immunodeficiency virus (HIV); Placebo; Antiretroviral therapy; Randomized controlled trial; Antibody; Clinical trial; Internal medicine; Virology; Immunology; Alternative medicine; Viral load; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0733861,0.007696117,0.009841196,0.001905159,0.003190482,0.005021341,0.004907277,0.01099449,0.0191351],"category_scores_gemma":[0.05796709,0.003857736,0.006425968,0.002398308,0.007423526,0.004740397,0.002765227,0.009994737,0.007223456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002918227,"about_ca_system_score_gemma":0.01054191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000934292,"about_ca_topic_score_gemma":0.00213093,"domain_scores_codex":[0.9168859,0.06768233,0.004605473,0.003783142,0.004457098,0.002586111],"domain_scores_gemma":[0.9807313,0.006482522,0.003428265,0.003521272,0.00275331,0.003083323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9413288,0.004360335,0.001084707,0.01212411,0.002231659,0.0002112053,0.0003832876,0.001183637,0.00242856,0.00782957,0.007364163,0.01947002],"study_design_scores_gemma":[0.9501269,0.02152783,0.001104549,0.001574958,0.001399667,0.00008494873,0.00008203097,0.001532976,0.0005741747,0.003284582,0.01858466,0.0001226523],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006218954,0.001913205,0.004810294,0.001132607,0.001482122,0.9810105,0.001153969,0.0001767598,0.002101571],"genre_scores_gemma":[0.01045804,0.0004762571,0.009131186,0.0009749326,0.0003252233,0.9774227,0.0002994052,0.00002179935,0.0008906176],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0733861,"threshold_uncertainty_score":0.3881074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.141724767663537,"score_gpt":0.4307024151140249,"score_spread":0.2889776474504879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}