{"id":"W3181021006","doi":"10.1126/science.aba5483","title":"Gut microbiome heritability is nearly universal but environmentally contingent","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; Centre Hospitalier Universitaire Sainte-Justine; Montreal Heart Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institute of Child Health and Human Development; National Science Foundation of Sri Lanka; Princeton University; National Institute on Aging; Duke University; National Institutes of Health; National Science Foundation","keywords":"Heritability; Microbiome; Biology; Host (biology); Feces; Zoology; Ecology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002637118,0.00008243714,0.0000755468,0.00001897084,0.000214265,0.00004594263,0.0002387133,0.00005470808,0.0001616842],"category_scores_gemma":[0.00002431089,0.00008494481,0.00004558609,0.0001504613,0.0005008196,0.000007322094,0.000273561,0.00005542186,0.00005653175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005455521,"about_ca_system_score_gemma":0.0004013664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002807071,"about_ca_topic_score_gemma":0.00002660835,"domain_scores_codex":[0.9989617,0.00002657379,0.0001090707,0.0004627357,0.0001071617,0.0003327641],"domain_scores_gemma":[0.9994453,0.000002720629,0.00003622762,0.0003488067,0.00005622295,0.0001107437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006019873,0.00004237184,0.003299409,0.000007498882,0.000003204583,0.000004145111,0.000087155,7.322166e-7,0.9956133,0.00001762627,0.0004044485,0.0005140337],"study_design_scores_gemma":[0.0002387466,0.00008028347,0.06964018,0.000005853737,0.00000404291,0.00003121966,0.0003182252,0.000005111623,0.8470454,0.0000140131,0.08248631,0.0001305692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976,0.0005103266,0.0001441439,0.0005481447,0.0001639583,0.00007305532,0.00003642427,0.000006104717,0.0009178562],"genre_scores_gemma":[0.9946904,0.0001071205,0.00152073,0.001058498,0.00004407078,0.00000112222,0.00001989201,0.000005642371,0.002552569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1485679,"threshold_uncertainty_score":0.3463949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00656238387020609,"score_gpt":0.2359986117360234,"score_spread":0.2294362278658173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}