{"id":"W3181021006","doi":"10.1126/science.aba5483","title":"Gut microbiome heritability is nearly universal but environmentally contingent","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; Centre Hospitalier Universitaire Sainte-Justine; Montreal Heart Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institute of Child Health and Human Development; National Science Foundation of Sri Lanka; Princeton University; National Institute on Aging; Duke University; National Institutes of Health; National Science Foundation","keywords":"Heritability; Microbiome; Biology; Host (biology); Feces; Zoology; Ecology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001206081,0.0002308432,0.0004067417,0.0005870504,0.0003320261,0.0004733444,0.0001218852,0.0002048902,0.002334867],"category_scores_gemma":[0.002306327,0.0001970908,0.0001962092,0.0006600794,0.0005302035,0.000326409,0.0005714872,0.0003095194,0.0002080376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001054376,"about_ca_system_score_gemma":0.0001421116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445233,"about_ca_topic_score_gemma":0.002361982,"domain_scores_codex":[0.9992529,0.0002285267,0.00003785472,0.0003224676,0.0000947182,0.00006359006],"domain_scores_gemma":[0.9983122,0.0006011578,0.0005137515,0.000347421,0.0001158718,0.0001094702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001581185,0.00002388633,0.9450003,0.00005764309,0.0006367868,0.0002523049,0.0004791316,0.0003297399,0.03358348,0.0004854989,0.0002589413,0.01873412],"study_design_scores_gemma":[0.000001378553,0.0000306432,0.9979575,0.000007605998,0.0000459694,0.0002541592,0.0001219734,0.0001529284,0.0008259529,0.0002575176,0.0003383298,0.000006066957],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961542,0.000553272,0.002035503,0.00004499002,0.00001036998,0.000003009037,0.0004739657,0.00002425937,0.0007004483],"genre_scores_gemma":[0.9992379,0.0001005579,0.0003753672,0.00001534516,0.00000550029,0.000002169812,0.0001578376,0.000005663059,0.00009975542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002334867,"threshold_uncertainty_score":0.007810891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00656238387020609,"score_gpt":0.2359986117360234,"score_spread":0.2294362278658173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}