{"id":"W3181052154","doi":"10.3390/biom11070979","title":"Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"General Secretariat for Research and Technology; Victoria University","keywords":"Angiotensin II; Candesartan; Angiotensin II receptor type 1; Receptor; Vasoconstriction; Angiotensin receptor; Chemistry; Pharmacology; Renin–angiotensin system; Internal medicine; Endocrinology; Medicine; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354766,0.0001922402,0.0002259489,0.00008056845,0.0001588639,0.00002878611,0.0001193676,0.0001384013,0.0002379664],"category_scores_gemma":[0.0005242406,0.000197244,0.0001315257,0.0002428593,0.0001051053,0.000005644285,0.000235403,0.0000707425,0.00001569945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002882981,"about_ca_system_score_gemma":0.0001791358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006538683,"about_ca_topic_score_gemma":0.00007542173,"domain_scores_codex":[0.9987385,0.00008326016,0.0002733818,0.0005079498,0.0001451719,0.0002517358],"domain_scores_gemma":[0.9990082,0.00002918433,0.00009890107,0.0003480374,0.0002315547,0.0002841611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000802141,0.00006704055,0.00006177164,0.00001515235,0.00006642157,0.000007071829,0.0001627206,0.00001564002,0.9489486,0.0002969016,0.04800267,0.002275835],"study_design_scores_gemma":[0.0002279509,0.0001692236,0.00002242434,0.00002675746,0.0000138905,0.00002918611,0.0001716464,0.00001647507,0.6469879,0.00004059444,0.3521346,0.0001593982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968096,0.003040406,0.01691642,0.01086675,0.0005684844,0.0002332127,0.0001464429,0.00003209306,0.0001002206],"genre_scores_gemma":[0.8669546,0.0006733965,0.1258484,0.003239969,0.0004004852,0.00002021174,0.0003237074,0.00006123512,0.002478075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3041319,"threshold_uncertainty_score":0.8043376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595368972760123,"score_gpt":0.2793638157114551,"score_spread":0.2634101259838539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}