{"id":"W3181057038","doi":"10.1038/s41589-021-00829-z","title":"Mechanical strength of RNA knot in Zika virus protects against cellular defenses","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Research Council Canada; Canadian Institutes of Health Research; Government of Canada","keywords":"Exoribonuclease; Knot (papermaking); RNase P; RNA; Pseudoknot; Biology; Circular RNA; Cell biology; Genetics; Materials science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001882644,0.0002113612,0.0003595886,0.00004436055,0.00002458785,0.000006190799,0.0002791235,0.001407648,0.0000601975],"category_scores_gemma":[0.0008433287,0.0001887357,0.0001555948,0.0001674108,0.00009354065,0.000002190353,0.0002080268,0.0004666878,0.000007277074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001703314,"about_ca_system_score_gemma":0.0001096717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006065512,"about_ca_topic_score_gemma":0.00001513974,"domain_scores_codex":[0.9984993,0.0001713341,0.0003305917,0.0005572201,0.0001045027,0.0003370382],"domain_scores_gemma":[0.9992197,0.000061084,0.0001078017,0.0004105827,0.0001126532,0.00008814536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270818,0.0001406742,0.00005330511,0.0000307995,0.00003742552,0.00002230455,0.000007277338,7.726711e-7,0.9913253,0.001253462,0.0001010356,0.006900609],"study_design_scores_gemma":[0.0004764847,0.0001242319,0.00001418778,0.00003053392,0.000008357852,0.00000995238,0.00001562763,0.000006283837,0.9869891,0.001798915,0.01031971,0.0002066337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932978,0.004894924,0.0003366448,0.0001904559,0.0001771547,0.0001993077,0.00004941247,0.0000134266,0.0008409336],"genre_scores_gemma":[0.9956854,0.0003273067,0.002969911,0.0004443262,0.0001947717,0.00003685259,0.0002592797,0.00002195611,0.00006017648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021867,"threshold_uncertainty_score":0.9998887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007503163705520293,"score_gpt":0.2402137877673233,"score_spread":0.232710624061803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}