{"id":"W3181158106","doi":"10.3389/fnmol.2021.680280","title":"Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cell biology; Progenitor cell; Wnt signaling pathway; Conditional gene knockout; Chromatin remodeling; Chromatin; Transcription factor; Sonic hedgehog; Cellular differentiation; Neurogenesis; Forebrain; Chromatin immunoprecipitation; Promoter; Stem cell; Gene expression; Genetics; Neuroscience; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002617479,0.0002146326,0.0002137702,0.00007828202,0.0002211409,0.0001135177,0.0002738584,0.0001271083,9.712605e-7],"category_scores_gemma":[0.000298274,0.0002309293,0.00007811785,0.0002180563,0.000121283,0.00001915381,0.000323484,0.00009838867,2.284951e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005780854,"about_ca_system_score_gemma":0.00007824568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003670605,"about_ca_topic_score_gemma":0.00001897307,"domain_scores_codex":[0.9981276,0.0001085569,0.0003156706,0.0008782875,0.0001753123,0.0003945612],"domain_scores_gemma":[0.9992778,0.00001041373,0.0001516408,0.0003985139,0.00006409919,0.00009753139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004013934,0.00004638599,0.01714096,0.00006638481,0.000004662296,0.0000109715,0.00007226124,0.0006079046,0.9810266,0.000006814384,0.00006870392,0.0009081571],"study_design_scores_gemma":[0.001242751,0.0002992236,0.03512323,0.00002645581,0.00003566999,0.00005004521,0.00009042854,0.4236086,0.5381783,0.0006897234,0.0001804757,0.000475113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8867908,0.0004084046,0.1118324,0.0001129599,0.000347556,0.000452683,0.00002890131,0.0000151041,0.00001120034],"genre_scores_gemma":[0.9800525,0.0001277411,0.01923381,0.0002423563,0.00002187165,0.00004869448,0.0001815965,0.00003089558,0.00006051821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4428484,"threshold_uncertainty_score":0.9417024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022239930486877,"score_gpt":0.2357853322470961,"score_spread":0.2255629329422273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}