{"id":"W3181158106","doi":"10.3389/fnmol.2021.680280","title":"Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cell biology; Progenitor cell; Wnt signaling pathway; Conditional gene knockout; Chromatin remodeling; Chromatin; Transcription factor; Sonic hedgehog; Cellular differentiation; Neurogenesis; Forebrain; Chromatin immunoprecipitation; Promoter; Stem cell; Gene expression; Genetics; Neuroscience; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007931892,0.0003988019,0.0001914412,0.0002405954,0.0001160663,0.0002260342,0.0001964303,0.0002425913,0.001811438],"category_scores_gemma":[0.00006603356,0.0001823198,0.0002353983,0.0001063789,0.0002333887,0.0001466578,0.0002149478,0.0005088579,0.0004295906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554072,"about_ca_system_score_gemma":0.0001265345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008259683,"about_ca_topic_score_gemma":0.00201676,"domain_scores_codex":[0.9998682,0.000009193184,0.00001481346,0.00004256086,0.00003728609,0.00002804428],"domain_scores_gemma":[0.9999009,0.0000107288,0.0000324116,0.00001046578,0.000009352781,0.00003613831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002751884,0.000004937476,0.0001131936,0.000009590314,0.000001574516,0.00002370311,0.000004911396,0.00001175354,0.9994854,0.00001821681,0.00001033542,0.0002888908],"study_design_scores_gemma":[0.000004490616,0.00006954523,0.006808733,0.000002909664,0.000004932579,0.0001571838,0.00001785713,0.0002710655,0.9916447,0.00001786284,0.0009988875,0.00000178875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950033,0.000724745,0.002517583,0.00005317605,0.00002581328,0.000009561603,0.0006588117,0.00009107554,0.0009159145],"genre_scores_gemma":[0.9905719,0.0004528471,0.001858811,0.00004180854,0.000006538315,0.00002827774,0.001255251,0.0000445532,0.00574017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811438,"threshold_uncertainty_score":0.006059885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022239930486877,"score_gpt":0.2357853322470961,"score_spread":0.2255629329422273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}