{"id":"W3181165699","doi":"10.1158/1538-7445.am2021-285","title":"Abstract 285: Development of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as new antimitotic cytochrome P450 1A1-activated prodrugs selective toward breast cancers: Evaluation of branched alkyl chains","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec; Université Laval","funders":"","keywords":"Prodrug; Chemistry; Cancer cell; Pharmacology; Sulforhodamine B; Cell cycle; Cancer research; Cancer; Biochemistry; Stereochemistry; In vitro; Cell; Cytotoxicity; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009717969,0.0003152366,0.0005216434,0.0001300963,0.0002475319,0.00005315935,0.0005170495,0.0002551868,0.00433096],"category_scores_gemma":[0.0006491893,0.0003382615,0.0001346833,0.001361137,0.0002332706,0.0002070497,0.0001990517,0.0006520703,0.00002255743],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001711351,"about_ca_system_score_gemma":0.01405824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291315,"about_ca_topic_score_gemma":0.0002698329,"domain_scores_codex":[0.9958028,0.00008862276,0.0007576081,0.0008343993,0.0018182,0.0006983888],"domain_scores_gemma":[0.9953477,0.0003074628,0.0003427536,0.0006831831,0.002969166,0.0003497096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002344684,0.0003065319,0.0002046731,0.0008528895,0.0003190722,0.000005024101,0.002949848,0.0006644524,0.9717642,0.00007519485,0.0006247259,0.02199892],"study_design_scores_gemma":[0.001527447,0.00001440587,0.005177001,0.000669928,0.00006791846,0.00002054607,0.001724168,0.00020219,0.9890028,0.0004401988,0.0008349611,0.0003183832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882166,0.001246186,0.00002196183,0.0008515129,0.00003570596,0.0004820395,0.0001982255,0.00005558883,0.008892164],"genre_scores_gemma":[0.9972631,0.0002786726,0.000218347,0.00001914484,0.0003092789,0.0005489932,0.0002491002,0.00005186088,0.001061441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02168054,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.137796806438427,"score_gpt":0.4193685479334143,"score_spread":0.2815717414949873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}