{"id":"W3181165699","doi":"10.1158/1538-7445.am2021-285","title":"Abstract 285: Development of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as new antimitotic cytochrome P450 1A1-activated prodrugs selective toward breast cancers: Evaluation of branched alkyl chains","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec; Université Laval","funders":"","keywords":"Prodrug; Chemistry; Cancer cell; Pharmacology; Sulforhodamine B; Cell cycle; Cancer research; Cancer; Biochemistry; Stereochemistry; In vitro; Cell; Cytotoxicity; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006660197,0.0002391792,0.0001411052,0.00009915282,0.00005055337,0.00009238369,0.000114986,0.0001488974,0.001034548],"category_scores_gemma":[0.00006006855,0.00006251531,0.00009359897,0.00009225577,0.00006734236,0.00009732677,0.00008040044,0.0001820527,0.0004066225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359121,"about_ca_system_score_gemma":0.0001523891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003009754,"about_ca_topic_score_gemma":0.000458316,"domain_scores_codex":[0.9999605,0.000007439643,0.000003247435,0.000007260951,0.00001374546,0.000007805897],"domain_scores_gemma":[0.9999698,0.000002979044,0.000009992827,0.000001888892,0.000008285007,0.000006885066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006837962,0.00002334153,0.00008151309,0.00005152275,0.000002577553,0.00003005396,0.000005465131,0.000122719,0.9973641,0.00006783752,0.00004549087,0.002136978],"study_design_scores_gemma":[0.00002112935,0.0005519377,0.0007947758,0.000002274927,0.000005988824,0.00008645288,0.000004238911,0.0004189574,0.9959345,0.00001413794,0.002163691,0.000001991358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904603,0.002211049,0.004357549,0.00008692474,0.00002797069,0.00006009037,0.0002909154,0.00005849106,0.002446701],"genre_scores_gemma":[0.990012,0.001523786,0.003824088,0.00004250766,0.000008479458,0.00003341639,0.000479686,0.00001188258,0.004064198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034548,"threshold_uncertainty_score":0.003460944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.137796806438427,"score_gpt":0.4193685479334143,"score_spread":0.2815717414949873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}