{"id":"W3181218975","doi":"10.1038/s41409-021-01393-9","title":"Increased donor inhibitory KIR with known HLA interactions provide protection from relapse following HLA matched unrelated donor HCT for AML","year":2021,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Human leukocyte antigen; Immunology; Haplotype; Transplantation; Internal medicine; Receptor; Lower risk; Oncology; Biology; Antigen; Allele; Gene; Confidence interval; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188411,0.0002039154,0.0004192087,0.0001317447,0.0001364432,0.000316891,0.0002886565,0.0001900422,0.001178791],"category_scores_gemma":[0.00037557,0.00009140863,0.0001812437,0.00009963211,0.0002530015,0.0002212208,0.0002642829,0.000906973,0.0002121217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662722,"about_ca_system_score_gemma":0.0002347863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002824172,"about_ca_topic_score_gemma":0.0006408585,"domain_scores_codex":[0.9998711,0.00003449436,0.000008588078,0.00001353196,0.00002018373,0.0000520678],"domain_scores_gemma":[0.9998141,0.00003189124,0.00004497305,0.00003180735,0.000007011171,0.00007029768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05073284,0.00938763,0.0251687,0.0003232948,0.0002950492,0.0007155914,0.0002578872,0.001245671,0.7553486,0.001273915,0.001803885,0.1534469],"study_design_scores_gemma":[0.005120668,0.1736464,0.421967,0.0001517785,0.001112314,0.005812546,0.0006294518,0.004527271,0.3734152,0.001914585,0.0116287,0.00007404979],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988079,0.0004466239,0.0001112949,0.00003417903,0.00002646352,0.00001407358,0.00002332135,0.0000170754,0.0005190285],"genre_scores_gemma":[0.9994512,0.000147852,0.00006875241,0.00003625113,0.00001547817,0.000006592383,0.00004601666,0.000002316573,0.0002255814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178791,"threshold_uncertainty_score":0.003943503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124679390424504,"score_gpt":0.220641925673987,"score_spread":0.2093951317697419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}