{"id":"W3181243732","doi":"10.1016/j.celrep.2021.109375","title":"Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 European Research Council; Academy of Medical Sciences; Kennedy Trust for Rheumatology Research; Wellcome Trust","keywords":"T-cell receptor; CD3; Allosteric regulation; Cell biology; Biology; Transmembrane protein; Signal transduction; Major histocompatibility complex; T cell; Receptor; Chemistry; Antigen; Biochemistry; Genetics; CD8; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001376609,0.0001648374,0.0002913772,0.00008662391,0.00006624361,0.000008591576,0.00008832745,0.0003675617,0.001204492],"category_scores_gemma":[0.00004102749,0.0001609236,0.00007371037,0.0001882363,0.00007143107,0.0001037029,0.00006846149,0.0002733396,0.00004349521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004404546,"about_ca_system_score_gemma":0.0001000517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001163702,"about_ca_topic_score_gemma":0.000005040163,"domain_scores_codex":[0.9985476,0.0001770249,0.0005826636,0.0003902939,0.0000470456,0.0002554221],"domain_scores_gemma":[0.9989323,0.00006633221,0.0005449444,0.0003394685,0.0001023596,0.00001458142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004765483,0.0001856875,0.01108861,0.00004872449,0.00002764295,0.00007367168,0.0003626819,0.0000262184,0.9855372,0.00000348471,0.00208513,0.000513274],"study_design_scores_gemma":[0.000456354,0.00007378194,0.0007139842,0.00003728961,0.00001390789,0.0001129349,0.0002300735,0.000002548148,0.9802707,0.00009769998,0.01783166,0.000159091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940675,0.00265034,0.00009807781,0.00005548778,0.0009326476,0.0001392756,0.00001009116,0.0000300786,0.002016431],"genre_scores_gemma":[0.9894688,0.0001681508,0.000181613,0.00004105919,0.00002134407,0.000004884896,0.0007498252,0.00001979528,0.009344558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01574653,"threshold_uncertainty_score":0.9997085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00811814725298083,"score_gpt":0.2056979791815763,"score_spread":0.1975798319285955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}