{"id":"W3181243732","doi":"10.1016/j.celrep.2021.109375","title":"Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 European Research Council; Academy of Medical Sciences; Kennedy Trust for Rheumatology Research; Wellcome Trust","keywords":"T-cell receptor; CD3; Allosteric regulation; Cell biology; Biology; Transmembrane protein; Signal transduction; Major histocompatibility complex; T cell; Receptor; Chemistry; Antigen; Biochemistry; Genetics; CD8; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009174089,0.0001600068,0.0001345126,0.00004661439,0.0001665997,0.000237247,0.0001776665,0.00017021,0.001367153],"category_scores_gemma":[0.0001923729,0.0001033256,0.000135291,0.00004398919,0.0003099739,0.0002172594,0.0002009126,0.0002858497,0.0002283503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002214284,"about_ca_system_score_gemma":0.0001498817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00028154,"about_ca_topic_score_gemma":0.0003557695,"domain_scores_codex":[0.9999461,0.0000116811,0.000002750146,0.000009223005,0.00001506425,0.00001524688],"domain_scores_gemma":[0.9999503,0.0000153821,0.00001291532,0.000006319782,0.000004897649,0.00001021587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009341707,0.00004011699,0.0003114036,0.00004132052,0.000005790131,0.0000776099,0.0000307269,0.001918818,0.9941239,0.001615436,0.00008043353,0.00166102],"study_design_scores_gemma":[0.0001110125,0.0004895529,0.003236684,0.000008950852,0.00001901503,0.0003752766,0.00006307036,0.05977748,0.9319384,0.001570603,0.002389575,0.00002038638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950821,0.0001625602,0.003373265,0.0000827504,0.00002026716,0.00001372119,0.00001877435,0.00007355385,0.001172976],"genre_scores_gemma":[0.998952,0.0000983865,0.0006880821,0.00002377607,0.000003518615,0.000006036406,0.00001530399,0.000007224784,0.0002055509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367153,"threshold_uncertainty_score":0.004573584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00811814725298083,"score_gpt":0.2056979791815763,"score_spread":0.1975798319285955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}