{"id":"W3181287254","doi":"10.1126/sciadv.abg7444","title":"The H3K36me2 writer-reader dependency in H3K27M-DIPG","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; NYU Grossman School of Medicine; National Institute of Neurological Disorders and Stroke; Directorate for Geosciences; National Institutes of Health; European Commission; York University; Alex's Lemonade Stand Foundation for Childhood Cancer; Deutsche Forschungsgemeinschaft; Constellation Pharmaceuticals; Hyundai Hope On Wheels; New York State Stem Cell Science; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Making Headway Foundation; American Cancer Society; Simons Foundation; Howard Hughes Medical Institute","keywords":"Chromatin; Histone; Carcinogenesis; Histone H3; Biology; Epigenome; Epigenetics; Cell biology; Chemistry; Genetics; DNA methylation; Cancer; DNA; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004442724,0.00006876574,0.00005461883,0.00002689414,0.0002215364,0.0000704722,0.0002766797,0.00003592506,0.00000930606],"category_scores_gemma":[0.0003291733,0.00005057291,0.00002756403,0.0003434097,0.000290265,0.00001595812,0.0001008019,0.00005615224,0.000007315257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001160321,"about_ca_system_score_gemma":0.0001812633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006662041,"about_ca_topic_score_gemma":0.0004424698,"domain_scores_codex":[0.9990451,0.00003412176,0.0001367637,0.0003236534,0.0002097236,0.0002506363],"domain_scores_gemma":[0.9994583,0.00002415485,0.00003888098,0.000311932,0.0001199104,0.00004682361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005047106,0.00001710529,0.0124602,0.000002741088,0.000001256293,0.000003046912,0.0000399145,0.0001705755,0.9229455,0.0002083458,0.00001165435,0.06413461],"study_design_scores_gemma":[0.0001113263,0.00004069927,0.01461594,0.000006582454,0.000001327286,0.000002488032,0.0002510044,0.00003628742,0.9106329,0.002958287,0.07125211,0.00009101975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670213,0.02618081,0.0008550779,0.0004896568,0.0003622938,0.0000672525,0.000002332896,0.000004708574,0.005016567],"genre_scores_gemma":[0.9960917,0.001489207,0.001123064,0.0000900556,0.00007772788,0.000009732528,0.000005939404,0.000004515086,0.00110808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07124045,"threshold_uncertainty_score":0.2062303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069724836940641,"score_gpt":0.302547904358136,"score_spread":0.2918506559887296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}