{"id":"W3181287254","doi":"10.1126/sciadv.abg7444","title":"The H3K36me2 writer-reader dependency in H3K27M-DIPG","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; NYU Grossman School of Medicine; National Institute of Neurological Disorders and Stroke; Directorate for Geosciences; National Institutes of Health; European Commission; York University; Alex's Lemonade Stand Foundation for Childhood Cancer; Deutsche Forschungsgemeinschaft; Constellation Pharmaceuticals; Hyundai Hope On Wheels; New York State Stem Cell Science; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Making Headway Foundation; American Cancer Society; Simons Foundation; Howard Hughes Medical Institute","keywords":"Chromatin; Histone; Carcinogenesis; Histone H3; Biology; Epigenome; Epigenetics; Cell biology; Chemistry; Genetics; DNA methylation; Cancer; DNA; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008847284,0.0001853819,0.0001406301,0.0001208536,0.0001366218,0.0001230467,0.00015674,0.0001649931,0.001702365],"category_scores_gemma":[0.00007469129,0.0001222186,0.0002260377,0.00009264446,0.0002275848,0.00009973782,0.0001651294,0.0004067439,0.0002998198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275852,"about_ca_system_score_gemma":0.0001643635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001169886,"about_ca_topic_score_gemma":0.001907008,"domain_scores_codex":[0.9998937,0.00001139549,0.000007566441,0.00002846491,0.00003414304,0.00002491306],"domain_scores_gemma":[0.9999379,0.00001167556,0.00001631918,0.0000079991,0.00000567456,0.00002035018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007564531,0.000008360449,0.0001292469,0.00001347404,0.000002550916,0.00002699996,0.000003717882,0.00001866348,0.9993718,0.00001965797,0.00001078799,0.000319069],"study_design_scores_gemma":[0.000006796236,0.0001394297,0.003899375,9.730884e-7,0.000004418863,0.0001805561,0.000008716543,0.0002608855,0.9947873,0.00001681222,0.0006927809,0.000002042754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968901,0.0007587126,0.001092009,0.00006539036,0.0000179287,0.00001572338,0.0002499128,0.00003108861,0.0008790416],"genre_scores_gemma":[0.997179,0.0002351368,0.0006914805,0.0000386029,0.000002922044,0.00001568519,0.0003113886,0.000008276555,0.00151757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702365,"threshold_uncertainty_score":0.005694985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069724836940641,"score_gpt":0.302547904358136,"score_spread":0.2918506559887296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}