{"id":"W3181312404","doi":"10.1158/1538-7445.am2021-lb094","title":"Abstract LB094: KisoBody: Development and pre-clinical assessment of a novel multispecific antibody platform","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Monoclonal antibody; Antibody; Cancer; Computational biology; Pharmacokinetics; Cancer research; Biology; Pharmacology; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001217809,0.0006105079,0.0004563146,0.0005080514,0.0002299858,0.0007782717,0.000804943,0.0009045299,0.003783861],"category_scores_gemma":[0.0005253972,0.0002562438,0.0003414335,0.0002317987,0.0003667544,0.0005283348,0.0005880733,0.001422053,0.001916215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006489915,"about_ca_system_score_gemma":0.0009070435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006748806,"about_ca_topic_score_gemma":0.0007210947,"domain_scores_codex":[0.999577,0.00008023649,0.00002074335,0.00005601538,0.000154785,0.0001111887],"domain_scores_gemma":[0.9997019,0.00002824226,0.00004461376,0.00002292738,0.00009780097,0.0001044453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002547921,0.003756637,0.001249803,0.0003684246,0.0000798414,0.000285684,0.00009409608,0.001943319,0.9217709,0.0005892694,0.003607538,0.06370655],"study_design_scores_gemma":[0.001736753,0.0711114,0.008145745,0.000102912,0.0001966824,0.001540214,0.00009058876,0.005403128,0.8572725,0.0003851948,0.05395542,0.00005943744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.939354,0.007957533,0.03298005,0.001494533,0.000340027,0.00273183,0.002263066,0.001129212,0.01174957],"genre_scores_gemma":[0.9593717,0.00412335,0.01931106,0.0008675597,0.00009612608,0.001195716,0.005133865,0.0001916109,0.009708974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003783861,"threshold_uncertainty_score":0.01265824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2984530107632288,"score_gpt":0.5658075367731463,"score_spread":0.2673545260099175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}