{"id":"W3181340735","doi":"10.1038/s41380-021-01208-9","title":"Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing","year":2021,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Medical Research Council; Grantová Agentura České Republiky","keywords":"Perineuronal net; Neuroplasticity; Neuroscience; Chondroitin sulphate; Long-term potentiation; Ageing; Synaptic plasticity; Chondroitin; Memory impairment; Genetically modified mouse; Cognition; Biology; Psychology; Transgene; Medicine; Internal medicine; Biochemistry; Glycosaminoglycan; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147363,0.0002627499,0.0002280716,0.0001671292,0.0001185516,0.0001965097,0.0001352376,0.0002372167,0.0005320931],"category_scores_gemma":[0.0001102488,0.00009576458,0.0001863144,0.00009308502,0.0002430245,0.0001742073,0.000189386,0.0002397426,0.0001665697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677165,"about_ca_system_score_gemma":0.0001888787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059505,"about_ca_topic_score_gemma":0.001189188,"domain_scores_codex":[0.9999315,0.000008984443,0.000009840772,0.00001370419,0.00002061956,0.00001534978],"domain_scores_gemma":[0.9998463,0.000005701036,0.00005954819,0.00001206928,0.00002548802,0.00005079946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008054588,0.000005266204,0.0004873995,0.00001673162,0.000003124339,0.00005627338,0.00001452881,0.00001347489,0.9986343,0.00003724434,0.000007787371,0.000643257],"study_design_scores_gemma":[0.00001659698,0.000581429,0.1192661,0.00001785916,0.00004372813,0.0009336679,0.0001042873,0.0005806641,0.8759089,0.0002936439,0.002241947,0.0000112571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995944,0.002200133,0.001079237,0.00004388993,0.00001363296,0.000008876757,0.0001429775,0.00003295755,0.0005343437],"genre_scores_gemma":[0.9969735,0.0008227839,0.0007390124,0.00001692111,0.000005305608,0.000009730888,0.0001777439,0.000006414175,0.00124851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059505,"threshold_uncertainty_score":0.002106726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817546019824376,"score_gpt":0.2707211738143046,"score_spread":0.2609036277944802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}