{"id":"W3181344481","doi":"10.1161/circresaha.120.318364","title":"A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling","year":2021,"lang":"en","type":"article","venue":"Circulation Research","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Pressure overload; Biology; Genetically modified mouse; Circular RNA; Gene isoform; RNA splicing; Periostin; Transgene; Ventricular remodeling; Fibrosis; Cell biology; Alternative splicing; RNA; RNA-binding protein; Gene silencing; Heart failure; Internal medicine; Gene; Medicine; Genetics; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006385804,0.0001324494,0.0001694869,0.0001230432,0.0002102204,0.0001045062,0.0002017946,0.0001655071,0.00004642669],"category_scores_gemma":[0.0008083732,0.0001582194,0.0001450546,0.0006332159,0.00007009325,0.000007634811,0.0001085437,0.0001999847,0.00005834924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005422876,"about_ca_system_score_gemma":0.0002970972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000412805,"about_ca_topic_score_gemma":0.00001563631,"domain_scores_codex":[0.9979004,0.0003081379,0.0002486212,0.0005844269,0.0004724415,0.000485918],"domain_scores_gemma":[0.9983416,0.00005507325,0.00002499605,0.0006009207,0.0007682889,0.0002091578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004806438,0.00006332332,0.009633243,0.00002268173,0.0000674584,0.000009769768,0.00004127159,0.002532485,0.9688423,0.000136231,0.01402322,0.004580005],"study_design_scores_gemma":[0.001576625,0.0001297676,0.05556509,0.00007707783,0.00005587257,0.00002368507,0.0002137273,0.006316471,0.6265272,0.001107064,0.3077595,0.000647919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768459,0.008798368,0.01093685,0.001382789,0.0001547069,0.000439487,0.00009343481,0.00003159348,0.001316849],"genre_scores_gemma":[0.9980122,0.0001262895,0.0001057413,0.000401151,0.0001359239,0.00006203507,0.00066185,0.00003774278,0.0004570419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.342315,"threshold_uncertainty_score":0.6452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054335936956148,"score_gpt":0.3661933050039207,"score_spread":0.3256499456343592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}