{"id":"W3181344481","doi":"10.1161/circresaha.120.318364","title":"A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling","year":2021,"lang":"en","type":"article","venue":"Circulation Research","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Pressure overload; Biology; Genetically modified mouse; Circular RNA; Gene isoform; RNA splicing; Periostin; Transgene; Ventricular remodeling; Fibrosis; Cell biology; Alternative splicing; RNA; RNA-binding protein; Gene silencing; Heart failure; Internal medicine; Gene; Medicine; Genetics; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113874,0.0003957074,0.0001346766,0.0001349331,0.0001132203,0.0001679409,0.0001200901,0.0002466781,0.0009091907],"category_scores_gemma":[0.0001078183,0.00008811694,0.0001550415,0.00007386547,0.0002891843,0.00004766392,0.0001431225,0.0002933513,0.0002739248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000259395,"about_ca_system_score_gemma":0.000181253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003040971,"about_ca_topic_score_gemma":0.0005001201,"domain_scores_codex":[0.9999471,0.000005300788,0.000003914181,0.00002044426,0.00001358874,0.000009658301],"domain_scores_gemma":[0.9998393,0.0000196862,0.00007553943,0.000009397793,0.00001328048,0.00004283007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001814311,0.00001341664,0.003117597,0.0000319188,0.000009129833,0.0005976158,0.00001456966,0.00006004682,0.9949969,0.0000577174,0.00006556668,0.0008540616],"study_design_scores_gemma":[0.0002200878,0.00103677,0.2552183,0.0000582275,0.0002696234,0.01719634,0.0001508301,0.003926013,0.7149679,0.0004607539,0.006471398,0.00002392139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979469,0.0005045297,0.0007888708,0.00006535277,0.00001341177,0.000006894065,0.0001402925,0.0000302041,0.0005035294],"genre_scores_gemma":[0.9978264,0.0002891439,0.0008061343,0.0000590621,0.00001774638,0.000009777918,0.0003201307,0.00001512057,0.0006564591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009091907,"threshold_uncertainty_score":0.003041506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054335936956148,"score_gpt":0.3661933050039207,"score_spread":0.3256499456343592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}