{"id":"W3181357699","doi":"10.1172/jci.insight.147096","title":"Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Institute of Dental and Craniofacial Research; University of California, San Diego; Dalhousie University; Division of Cancer Prevention, National Cancer Institute; National Cancer Institute; Tobacco-Related Disease Research Program","keywords":"Medicine; Metformin; PI3K/AKT/mTOR pathway; OPLS; Clinical trial; Internal medicine; Head and neck squamous-cell carcinoma; Biopsy; Pathology; Oncology; Cancer; Head and neck cancer; Signal transduction; Insulin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001526204,0.0003914796,0.0006583547,0.0002181039,0.0002128823,0.0005146828,0.0002405364,0.0004202726,0.001756926],"category_scores_gemma":[0.0007822131,0.0002001508,0.0004411701,0.0001571546,0.0003216168,0.0003521903,0.0002308245,0.0009153206,0.0001781131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003479283,"about_ca_system_score_gemma":0.0004984012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001771909,"about_ca_topic_score_gemma":0.0006528719,"domain_scores_codex":[0.9996556,0.000149352,0.0000279216,0.0000486339,0.00005541272,0.00006313171],"domain_scores_gemma":[0.9995533,0.0001075756,0.0001663884,0.00002810419,0.00003944841,0.0001052308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4321472,0.02656238,0.08445907,0.001493623,0.001178838,0.0001961533,0.0001692283,0.002060412,0.2058302,0.0003654945,0.001566887,0.2439706],"study_design_scores_gemma":[0.03712716,0.5626877,0.2856976,0.0001516751,0.001502791,0.0005580327,0.0002698393,0.005544042,0.09959295,0.0005640584,0.006255672,0.00004844808],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972594,0.001879367,0.0001544194,0.00009199281,0.00002596791,0.000135746,0.0000877619,0.00001059948,0.0003548104],"genre_scores_gemma":[0.9985656,0.0004532281,0.0002858757,0.00008261685,0.00002955985,0.0001265575,0.0001116045,0.000002764465,0.0003421902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756926,"threshold_uncertainty_score":0.008071423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03355189796375278,"score_gpt":0.3117152895762451,"score_spread":0.2781633916124923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}