{"id":"W3181379278","doi":"10.1016/j.chest.2021.07.009","title":"Precision Medicine and Heterogeneity of Treatment Effect in Therapies for ARDS","year":2021,"lang":"en","type":"review","venue":"CHEST Journal","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto","funders":"Xenios; Fresenius Medical Care North America","keywords":"Medicine; ARDS; Clinical trial; Population; Intensive care medicine; Disease; Precision medicine; Internal medicine; Pathology; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008497823,0.0002977636,0.00240711,0.0002447871,0.00003635491,0.00001116613,0.00006219075,0.0002127977,0.00006951093],"category_scores_gemma":[0.0001776709,0.0001530874,0.0004678325,0.0001122583,0.00005146306,0.00002914796,0.00001806268,0.0002242507,7.125908e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184234,"about_ca_system_score_gemma":0.0004141339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002269579,"about_ca_topic_score_gemma":0.000003799294,"domain_scores_codex":[0.9986369,0.0001484825,0.000653696,0.0002116681,0.0001745772,0.0001746991],"domain_scores_gemma":[0.9988988,0.0003113688,0.0003510654,0.0001999696,0.00007850669,0.000160286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004967379,0.00005793587,0.0002288424,0.009110292,0.0002924986,0.00009732963,0.0001352286,2.749197e-8,0.00009169041,0.000005423889,0.0001166662,0.9898144],"study_design_scores_gemma":[0.002165481,0.004511415,0.00006470332,0.02530289,0.001340132,0.0008487899,0.0000407591,8.814932e-7,0.0004505189,0.00003538148,0.9651332,0.0001057764],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003338363,0.9952661,0.0001515467,0.00004538593,0.0002741218,0.0008551368,0.000008377122,0.000004247236,0.00005668931],"genre_scores_gemma":[0.0001178171,0.9986299,0.0005416377,0.00002690836,0.0004439082,0.00006120107,0.00003176058,0.00003184416,0.0001150421],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897086,"threshold_uncertainty_score":0.6242724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1347350642032118,"score_gpt":0.430599021047643,"score_spread":0.2958639568444312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}