{"id":"W3181410333","doi":"10.1101/2021.07.09.21260221","title":"Genetic regulation of <i>OAS1</i> nonsense-mediated decay underlies association with risk of severe COVID-19","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Center for Clinical and Translational Science, University of Alabama at Birmingham; National Institutes of Health; Deutsche Forschungsgemeinschaft; Hellenic Foundation for Research and Innovation; European Commission; Oxford Nanopore Technologies; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Bundesministerium für Bildung und Forschung; Wayne and Gladys Valley Foundation; University of Alabama at Birmingham; National Human Genome Research Institute; University of Alabama; National Cancer Institute; Genomic Health; Kaiser Permanente; Frederick National Laboratory for Cancer Research; Robert Wood Johnson Foundation; Ellison Medical Foundation","keywords":"Haplotype; Locus (genetics); Genetics; Allele; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006431805,0.0002839343,0.0007016791,0.0002119495,0.00009049827,0.00001454228,0.0002513924,0.0008021361,0.0006175536],"category_scores_gemma":[0.001275117,0.0002461791,0.0001984429,0.000179147,0.0002282767,0.00003435748,0.0002291053,0.0006131383,0.00003869724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044519,"about_ca_system_score_gemma":0.0008457535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006165321,"about_ca_topic_score_gemma":0.0004207966,"domain_scores_codex":[0.9971485,0.001400837,0.0006652048,0.000399991,0.0001181921,0.0002673496],"domain_scores_gemma":[0.9965616,0.001112556,0.001298398,0.0005857222,0.0004098754,0.00003184833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001785837,0.000235141,0.4156544,0.0005333123,0.002052743,0.00001033776,0.002573959,0.001904384,0.5732313,0.00005304694,0.001592468,0.0003730496],"study_design_scores_gemma":[0.002050512,0.0003646518,0.5715404,0.0003532904,0.0005317555,0.00007456922,0.0008777294,0.0000284666,0.4196465,0.00009887409,0.00401609,0.0004171572],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993283,0.003776038,0.001066995,0.0002592505,0.0006277515,0.0003322436,0.0002427865,0.0000537734,0.0003581513],"genre_scores_gemma":[0.9957563,0.000956447,0.0002793728,0.00009717304,0.00001688746,0.00002111517,0.0004889938,0.00003058771,0.002353181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.155886,"threshold_uncertainty_score":0.999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371543505467988,"score_gpt":0.2429850945255829,"score_spread":0.229269659470903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}