{"id":"W3181418983","doi":"10.1101/2021.07.05.451124","title":"Direct neuronal reprogramming by temporal identity factors","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal; Krembil Foundation","keywords":"Reprogramming; Biology; Embryonic stem cell; Cell biology; Progenitor cell; Chromatin; Transcription factor; Neural stem cell; Progenitor; Cellular differentiation; Stem cell; Neuroscience; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003790964,0.0005787017,0.0004708923,0.00009295252,0.0001716667,0.0004135072,0.0005785682,0.0005990515,0.00004391589],"category_scores_gemma":[0.0003109032,0.0006385208,0.0002870596,0.0002658347,0.000121962,0.0000230896,0.0009018716,0.0004363919,0.0000118186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006878969,"about_ca_system_score_gemma":0.0005678039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001297842,"about_ca_topic_score_gemma":0.00001606677,"domain_scores_codex":[0.9970232,0.0001463445,0.0004681232,0.001390247,0.0004171382,0.000554927],"domain_scores_gemma":[0.9980733,0.0000144111,0.0003184526,0.001040575,0.0002990394,0.0002542715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002706571,0.0001311713,0.131924,0.0001425661,0.0001752512,0.00002308616,0.000006402548,0.000008010946,0.8654115,0.00001258789,0.002135735,0.000002620461],"study_design_scores_gemma":[0.0003806706,0.00007616654,0.1342656,0.0001149377,0.00007947754,1.6057e-8,0.00001522294,0.00001061877,0.8220473,5.469385e-7,0.04192634,0.001083094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941389,0.002928216,0.001204449,0.00006054391,0.001024212,0.0003611957,0.000107007,0.000126053,0.00004943982],"genre_scores_gemma":[0.9969596,0.0005797215,0.001809658,0.0001478706,0.0002415552,0.000080941,0.00002488954,0.0001148615,0.00004096248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04336422,"threshold_uncertainty_score":0.9996066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012176435439197,"score_gpt":0.2231069251735683,"score_spread":0.2129851608191763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}