{"id":"W3181496761","doi":"10.1002/cpt.2355","title":"Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies","year":2021,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Barts Charity; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research; National Institutes of Health","keywords":"Medicine; Pharmacogenomics; Antihypertensive drug; Internal medicine; Thiazide; Pharmacogenetics; Genome-wide association study; Blood pressure; Single-nucleotide polymorphism; Odds ratio; Pharmacology; Cardiology; Bioinformatics; Genotype; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03087263,0.004177044,0.007708726,0.005597436,0.001246008,0.004065712,0.002639408,0.002675847,0.002390716],"category_scores_gemma":[0.04262941,0.001609226,0.03885708,0.009320569,0.0007432441,0.001301057,0.002722702,0.003196075,0.0002454745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009859749,"about_ca_system_score_gemma":0.001573318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009935663,"about_ca_topic_score_gemma":0.01252734,"domain_scores_codex":[0.9534842,0.0324452,0.003855129,0.006118416,0.002809361,0.001287698],"domain_scores_gemma":[0.954704,0.03353792,0.003651761,0.005425253,0.001981764,0.0006992637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004447151,0.00004465274,0.1259645,0.002644894,0.8595247,0.0002642238,0.00007341758,0.001285302,0.0007188545,0.0002405264,0.0006540405,0.004137696],"study_design_scores_gemma":[0.001162138,0.0003091894,0.07905705,0.0004578967,0.9139658,0.0002377484,0.00007385724,0.002740472,0.0003275266,0.0006484074,0.0009768063,0.00004312293],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4775292,0.4721635,0.03328574,0.004049183,0.001300263,0.0006141861,0.007322215,0.0007516375,0.002984129],"genre_scores_gemma":[0.9734223,0.01412073,0.007861511,0.0009455165,0.0003526946,0.0005406276,0.00218385,0.0001475407,0.0004252603],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.03087263,"threshold_uncertainty_score":0.163272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4906266916372513,"score_gpt":0.531260397962451,"score_spread":0.04063370632519969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}