{"id":"W3181502328","doi":"10.1158/1538-7445.am2021-lb105","title":"Abstract LB105: In vivo CAR T therapy: targeted in vivo gene delivery of a CAR using a CD8-specific fusogen results in tumor eradication","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chimeric antigen receptor; Cytotoxic T cell; CD8; Ex vivo; Biology; Transduction (biophysics); T cell; Cancer research; Gene delivery; Viral vector; Cell therapy; CD19; In vivo; Genetic enhancement; Cell biology; Immunology; Antigen; Immune system; In vitro; Stem cell; Biochemistry; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275598,0.000473209,0.0002439177,0.0003124793,0.0001229654,0.0003061219,0.0002252273,0.0004808368,0.002213736],"category_scores_gemma":[0.00006707651,0.000101979,0.0001929922,0.0001436315,0.0001935727,0.0001958227,0.0001233053,0.0006518494,0.0006969622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003660908,"about_ca_system_score_gemma":0.0001429237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007834742,"about_ca_topic_score_gemma":0.0004536756,"domain_scores_codex":[0.9998797,0.00002004322,0.000008951001,0.00002680054,0.0000383098,0.00002620814],"domain_scores_gemma":[0.9999689,0.000005464146,0.000009436139,0.000004119342,0.000003458521,0.000008703448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009622196,0.00008442809,0.00006276827,0.0000256076,0.000003625828,0.00005018848,0.000006966859,0.0001090538,0.9961677,0.0001792912,0.0003292685,0.002884805],"study_design_scores_gemma":[0.00002287973,0.0005796414,0.0005787833,0.000003139611,0.00001162323,0.0002674604,0.000004060103,0.0008983588,0.9942904,0.00002629238,0.003314797,0.000002620015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610867,0.003465469,0.02317047,0.0004286858,0.0001440361,0.0001295907,0.0009360172,0.001111281,0.009527787],"genre_scores_gemma":[0.9841198,0.0008247833,0.005631302,0.000103649,0.00002491811,0.00004433648,0.001020256,0.00006867196,0.008162233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002213736,"threshold_uncertainty_score":0.007405698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1256036149349658,"score_gpt":0.4004026008070786,"score_spread":0.2747989858721128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}