{"id":"W3181534243","doi":"10.1371/journal.ppat.1009753","title":"COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Concordia University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Fonds de Recherche du Québec - Santé; Institut de Valorisation des Données","keywords":"Cohort; Immune system; Immunology; CD8; Disease; Coronavirus disease 2019 (COVID-19); Inflammation; Monocyte; Phenotype; Medicine; Biology; Cohort study; Internal medicine; Genetics; Infectious disease (medical specialty); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010904,0.000359686,0.0004682859,0.0002224198,0.0001864434,0.0006435798,0.0004806625,0.0004423399,0.002077294],"category_scores_gemma":[0.002059518,0.0002285644,0.0005578907,0.000140542,0.0003037248,0.0003573726,0.00047912,0.0005570576,0.0002130494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934498,"about_ca_system_score_gemma":0.0004373438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281653,"about_ca_topic_score_gemma":0.001094276,"domain_scores_codex":[0.9997624,0.0001023104,0.00001098051,0.00006337976,0.0000243655,0.00003673061],"domain_scores_gemma":[0.9992616,0.0003773797,0.0001332602,0.00009942062,0.00003913783,0.00008918392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.003579404,0.0005450004,0.3794086,0.0001330649,0.0004569379,0.001641156,0.0002336882,0.5702154,0.0201258,0.006971017,0.002285841,0.01440409],"study_design_scores_gemma":[0.0001841392,0.001245217,0.06357947,0.00002394779,0.0001621897,0.001413033,0.0002331167,0.9197004,0.005214573,0.006611878,0.001575913,0.00005611837],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799531,0.00007613358,0.01779119,0.0002190433,0.0000217184,0.00003842835,0.0009873803,0.0000645767,0.0008484009],"genre_scores_gemma":[0.9970725,0.00002987522,0.001961155,0.00003573404,0.000005366031,0.00002892964,0.0005462012,0.000006563234,0.0003136974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002077294,"threshold_uncertainty_score":0.006949186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175738397071571,"score_gpt":0.3172815792113639,"score_spread":0.2855241952406482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}