{"id":"W3181542836","doi":"10.1158/1538-7445.am2021-924","title":"Abstract 924: PROTECT, a novel antibody platform for integrating tumor-specific immune modulation and enhancing the therapeutic window of targeted multispecific biologics","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Antibody; Cancer research; Antigen; Immune system; Tumor microenvironment; Chemistry; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466189,0.000507283,0.0002000734,0.0002357781,0.00008761113,0.0002975843,0.0003542271,0.0004487761,0.001646474],"category_scores_gemma":[0.00008015593,0.0001437798,0.0002383905,0.00007645527,0.0001507969,0.0002937734,0.000299296,0.0005484385,0.0007066383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000263281,"about_ca_system_score_gemma":0.0001854118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001828191,"about_ca_topic_score_gemma":0.0001760409,"domain_scores_codex":[0.9999083,0.00001031621,0.000004232438,0.0000206227,0.00003452928,0.00002181387],"domain_scores_gemma":[0.9999536,0.000003996664,0.00001955542,0.000004346935,0.000005591432,0.00001283022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006026542,0.00003429114,0.00006098092,0.00004186623,0.000004980011,0.00004034277,0.000007340857,0.0002804716,0.9951794,0.0004620236,0.000204108,0.003623912],"study_design_scores_gemma":[0.00003467712,0.0004750513,0.0003444841,0.000003569706,0.00001035817,0.0002137974,0.000003644249,0.001298376,0.9913011,0.00007638513,0.006231918,0.000006651082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373661,0.002588713,0.04953451,0.0003039314,0.0001197519,0.0001293592,0.000672514,0.0006592693,0.008625926],"genre_scores_gemma":[0.966649,0.001061757,0.02345498,0.0001993324,0.00002865349,0.00008711084,0.0005619407,0.00005793985,0.007899134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646474,"threshold_uncertainty_score":0.005507946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1382783171316728,"score_gpt":0.4220520339317984,"score_spread":0.2837737168001256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}