{"id":"W3181587007","doi":"10.1101/2021.07.14.452331","title":"The J domain of sacsin disrupts intermediate filament assembly","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Muscular Dystrophy Canada; McGill University","keywords":"Intermediate filament; Cell biology; Neurofilament; Vimentin; Regulator; Biology; Protein filament; Gene; Chemistry; Cell; Cytoskeleton; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132575,0.0003663632,0.0001599139,0.0001823158,0.0001508374,0.0001981935,0.0002500353,0.0004154433,0.001079763],"category_scores_gemma":[0.0001102237,0.0001795194,0.0002539236,0.00009737654,0.0002511638,0.000124707,0.0001849287,0.0004155177,0.0003170484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889484,"about_ca_system_score_gemma":0.0001356111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006950244,"about_ca_topic_score_gemma":0.000887906,"domain_scores_codex":[0.9998527,0.00002807049,0.00002882955,0.00002670796,0.00003348253,0.00003014599],"domain_scores_gemma":[0.9998079,0.00004570993,0.00006154869,0.00001926337,0.00001220492,0.00005350799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004885891,0.00001802405,0.00006974331,0.00001921619,0.000003991852,0.00007317516,0.000007080644,0.0000277659,0.9994996,0.00004536449,0.00001204279,0.0001751481],"study_design_scores_gemma":[0.00002413142,0.0003669379,0.00343285,0.000008718719,0.00001657591,0.000551127,0.00002656082,0.001324416,0.9923983,0.00003450251,0.00181027,0.000005640788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975232,0.0004468902,0.001233964,0.00004398909,0.00003488978,0.00001461824,0.0001502678,0.00004309008,0.0005091284],"genre_scores_gemma":[0.9978176,0.0001432234,0.0007745093,0.00003035895,0.000006859458,0.00001050379,0.0002035419,0.00001441776,0.0009989925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079763,"threshold_uncertainty_score":0.003612161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140681059248949,"score_gpt":0.2565579393140749,"score_spread":0.2451511287215855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}