{"id":"W3181608279","doi":"10.1101/2021.06.29.21259427","title":"Convalescent plasma for hospitalized patients with COVID-19 and the effect of plasma antibodies: a randomized controlled, open-label trial","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Impact; University of British Columbia; Sinai Health System; Public Health Ontario; Mount Sinai Hospital; Health Sciences Centre; University of Calgary; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Héma-Québec; Canadian Blood Services; Université de Montréal; Public Health Agency of Canada; University of Ottawa; Kingston Health Sciences Centre; Sunnybrook Health Science Centre; Centre Hospitalier Universitaire Sainte-Justine; Ottawa Hospital; University of Toronto; McMaster University; Queen's University; Université Laval; Centre Hospitalier de l’Université de Montréal; University of Waterloo","funders":"Canadian Institutes of Health Research; University of Toronto; University of Alberta; Ottawa Hospital Foundation; Alberta Health Services; McMaster University; Ministry of Health, Saskatchewan; Health Sciences Centre Foundation; Fondation du CHUM","keywords":"Medicine; Randomized controlled trial; Confidence interval; Antibody; Relative risk; Internal medicine; Convalescent plasma; Adverse effect; Intubation; Gastroenterology; Coronavirus disease 2019 (COVID-19); Immunology; Anesthesia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007578958,0.0007224263,0.006826467,0.0002632689,0.0002071683,0.0002656226,0.000755401,0.0004245529,0.00001874203],"category_scores_gemma":[0.02226086,0.0003561624,0.0008127923,0.0002139438,0.001386355,0.00007159763,0.001051988,0.0007542949,0.000002978023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623681,"about_ca_system_score_gemma":0.001584163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003340355,"about_ca_topic_score_gemma":0.0000412591,"domain_scores_codex":[0.9934333,0.002393522,0.001390367,0.001048711,0.001167457,0.0005666188],"domain_scores_gemma":[0.9834185,0.01368714,0.00100118,0.001073273,0.0006346205,0.0001852959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9547601,0.0006899183,0.03601669,0.003377811,0.003645742,0.00005160847,0.0007385145,0.000001606941,0.0002087986,0.00009668771,0.0001474154,0.0002651144],"study_design_scores_gemma":[0.9830727,0.003510953,0.0001894202,0.0009192182,0.002895523,0.000008790708,0.00007705911,0.002452282,0.005122055,0.00007253998,0.001317601,0.0003618331],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.945932,0.001035434,0.0004295954,0.0008608818,0.0007424018,0.0504622,0.0001157194,0.00005019892,0.0003715573],"genre_scores_gemma":[0.9853492,0.0001345386,0.0003311051,0.004159712,0.0001861963,0.009545478,0.0001078203,0.00009784571,0.00008815031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04091672,"threshold_uncertainty_score":0.999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03258525038234056,"score_gpt":0.3549690183931977,"score_spread":0.3223837680108571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}