{"id":"W3181643986","doi":"10.3389/fimmu.2021.707463","title":"Efficacy, Safety and Tolerability of a New 10% Intravenous Immunoglobulin for the Treatment of Primary Immunodeficiencies","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Université Laval","funders":"","keywords":"Medicine; Tolerability; Confidence interval; Clinical endpoint; Adverse effect; Primary immunodeficiency; Incidence (geometry); Internal medicine; Pediatrics; Clinical trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001296272,0.0002600731,0.000745237,0.000149153,0.0001643893,0.0005397996,0.0004006999,0.0005111278,0.0008010383],"category_scores_gemma":[0.0006591923,0.0001257885,0.0005074914,0.0001354421,0.0003705038,0.000304717,0.0001699592,0.001216969,0.0001783948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004042294,"about_ca_system_score_gemma":0.0004618629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005601087,"about_ca_topic_score_gemma":0.001702641,"domain_scores_codex":[0.9994919,0.000253825,0.00003463995,0.0000592512,0.0000997357,0.00006059403],"domain_scores_gemma":[0.9995927,0.0001236719,0.0001154784,0.00003645917,0.00003927189,0.00009231548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1956275,0.02717806,0.0368433,0.001869262,0.001738847,0.0008778231,0.0004372394,0.00465714,0.198483,0.0003846444,0.003358659,0.5285446],"study_design_scores_gemma":[0.07034915,0.7912251,0.1012725,0.0001666372,0.0008830174,0.001605952,0.000117034,0.002492513,0.0247701,0.0001561963,0.006893322,0.00006851073],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942524,0.003836775,0.0004425617,0.0001779685,0.00004319722,0.000248272,0.0001842325,0.00003367105,0.0007809722],"genre_scores_gemma":[0.9965826,0.00129498,0.0007725097,0.000370139,0.00005194695,0.0001402945,0.0004844189,0.000006797939,0.0002964381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296272,"threshold_uncertainty_score":0.006855369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113338574928248,"score_gpt":0.2212691994767696,"score_spread":0.2101358137274871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}