{"id":"W3181720537","doi":"10.1126/science.abf6202","title":"Mapping the cellular origin and early evolution of leukemia in Down syndrome","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Ontario Institute for Cancer Research; SickKids Foundation; University Health Network; University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Canada Research Chairs; Canadian Cancer Society; Human Frontier Science Program; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer; Leukemia and Lymphoma Society; International Development Research Centre","keywords":"Trisomy; Preleukemia; Context (archaeology); Down syndrome; Leukemia; Aneuploidy; Biology; Genetics; Chromosome 21; Haploinsufficiency; Chromosome; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216362,0.0002334711,0.0001873383,0.0007059705,0.0002036651,0.0004608193,0.000218935,0.0004996874,0.0014548],"category_scores_gemma":[0.0002857914,0.0002605966,0.0001958218,0.0002658985,0.0002923757,0.0003647218,0.0005311205,0.0006780764,0.0004473628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836905,"about_ca_system_score_gemma":0.0001539101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162798,"about_ca_topic_score_gemma":0.001503186,"domain_scores_codex":[0.9999067,0.00001829648,0.000008708369,0.00002100684,0.0000236282,0.00002169992],"domain_scores_gemma":[0.9998795,0.00004123433,0.00002451869,0.00001250616,0.00001663092,0.00002547263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004151012,0.00002440029,0.006474857,0.00009381802,0.00002201899,0.001098192,0.0001276432,0.0001820192,0.9734046,0.002200492,0.0004552326,0.01550167],"study_design_scores_gemma":[0.0001052296,0.000689722,0.1565238,0.0001009833,0.0001491199,0.01529186,0.0004015945,0.001757502,0.7647678,0.001794829,0.05837578,0.00004176804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568151,0.01630579,0.01497548,0.0006169745,0.0002073569,0.00008326964,0.001136003,0.0001357296,0.009724253],"genre_scores_gemma":[0.9768444,0.01136642,0.006178838,0.0003113147,0.00003678506,0.00003891529,0.0006838661,0.00004393108,0.004495646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0014548,"threshold_uncertainty_score":0.004866779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02577887880929269,"score_gpt":0.2799756846992894,"score_spread":0.2541968058899967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}