{"id":"W3181728189","doi":"","title":"Glia-derived S100ß promotes pericyte-mediated capillary constriction and reduced blood flow in glaucomatous and ischemic retinas","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"","keywords":"Pericyte; Constriction; Blood flow; Ophthalmology; Medicine; Chemistry; Cell biology; Biology; Cardiology; Endothelial stem cell; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175341,0.000216625,0.000242116,0.0004121405,0.0002345228,0.0002943722,0.0001663389,0.0002724015,0.001199736],"category_scores_gemma":[0.0001565207,0.0001753128,0.0001774963,0.0002024963,0.0002639272,0.000290274,0.0002346664,0.000638153,0.0001598261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003791338,"about_ca_system_score_gemma":0.0002345308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00204244,"about_ca_topic_score_gemma":0.002367843,"domain_scores_codex":[0.9998949,0.00001761999,0.000007818377,0.00001478818,0.00002438607,0.0000404273],"domain_scores_gemma":[0.9999003,0.000017701,0.00002517288,0.00001133385,0.00001250082,0.00003290724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004534103,0.00003149126,0.0002300078,0.0000241063,0.000005214159,0.0001238697,0.00003390231,0.0000196667,0.9980662,0.0001732898,0.00004861607,0.0007901081],"study_design_scores_gemma":[0.0000675375,0.0003676504,0.02013696,0.000007543062,0.0000247618,0.0003957991,0.0001486641,0.001158967,0.9761706,0.0001710692,0.001346131,0.000004294839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976966,0.00068171,0.0007946804,0.00006725266,0.00002043497,0.000008504043,0.00007371327,0.00002763887,0.0006295102],"genre_scores_gemma":[0.9968517,0.000450474,0.0006983379,0.00003640104,0.00001228557,0.00001693823,0.0001141284,0.00001184614,0.00180799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204244,"threshold_uncertainty_score":0.004061043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513452955687823,"score_gpt":0.2762863398609092,"score_spread":0.261151810304031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}