{"id":"W3181840845","doi":"10.1126/science.abf8113","title":"A human apolipoprotein L with detergent-like activity kills intracellular pathogens","year":2021,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Australian Research Council; Medical Research Council Canada; National Institutes of Health; Helen Hay Whitney Foundation; Howard Hughes Medical Institute","keywords":"Extracellular; Intracellular; Intracellular parasite; Biology; Cytosol; Immune system; Cell biology; Bacteria; Microbiology; Biochemistry; Immunology; Enzyme; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001786646,0.000245238,0.0001258105,0.0001418558,0.0001215959,0.0002600396,0.0001575433,0.0002863805,0.0005774857],"category_scores_gemma":[0.0001415816,0.00009651476,0.0002112934,0.0000985331,0.0001885469,0.000105803,0.0001612246,0.0002565423,0.0003566779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351757,"about_ca_system_score_gemma":0.0001772731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000508415,"about_ca_topic_score_gemma":0.0006153156,"domain_scores_codex":[0.9999065,0.00001560313,0.000008932182,0.00001865736,0.00003438965,0.00001582951],"domain_scores_gemma":[0.9999418,0.000008768127,0.00001755236,0.000008519979,0.000009807539,0.00001356752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006055385,0.00001905486,0.0001612099,0.00001505935,0.000003485604,0.00003592134,0.000004142206,0.00002599741,0.9982302,0.00004958095,0.00004709646,0.001347841],"study_design_scores_gemma":[0.00001333258,0.0001757652,0.0007687428,0.000003676736,0.000009526629,0.0002570208,0.000008179522,0.000482038,0.9957879,0.00003533528,0.002456022,0.000002417157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854918,0.001942376,0.009377316,0.0002621169,0.00006207681,0.00005002503,0.0002863974,0.000243811,0.002284098],"genre_scores_gemma":[0.9884433,0.0007378628,0.007220981,0.000133035,0.000008186151,0.0000196922,0.0003679688,0.00003290507,0.003036173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005774857,"threshold_uncertainty_score":0.001931846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435682246986726,"score_gpt":0.2651085181725339,"score_spread":0.2507516957026666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}