{"id":"W3181840845","doi":"10.1126/science.abf8113","title":"A human apolipoprotein L with detergent-like activity kills intracellular pathogens","year":2021,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Australian Research Council; Medical Research Council Canada; National Institutes of Health; Helen Hay Whitney Foundation; Howard Hughes Medical Institute","keywords":"Extracellular; Intracellular; Intracellular parasite; Biology; Cytosol; Immune system; Cell biology; Bacteria; Microbiology; Biochemistry; Immunology; Enzyme; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002523951,0.00009936421,0.0001179288,0.00006893488,0.0005162461,0.00003752205,0.0002209097,0.00004996678,0.0007088674],"category_scores_gemma":[0.0000472222,0.00007217684,0.0000333486,0.0003992064,0.0007529873,0.0001226577,0.0001289589,0.0001582159,0.0009656274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006704455,"about_ca_system_score_gemma":0.0003493155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008540159,"about_ca_topic_score_gemma":0.0002067159,"domain_scores_codex":[0.9988311,0.00009253461,0.00007487313,0.0003924084,0.00009738249,0.0005117159],"domain_scores_gemma":[0.9994118,0.0000165244,0.00003177259,0.0003685703,0.0001051083,0.00006621188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001427319,0.0001549424,0.002452336,0.000003892845,0.00002338007,0.0001346694,0.0001437477,0.000001088897,0.9877931,0.0001106637,0.00007227895,0.009095648],"study_design_scores_gemma":[0.0005426991,0.0002346031,0.02336879,0.00001319686,0.000008964776,0.0001118963,0.00008237953,0.000001677898,0.9672211,0.00005157854,0.008257867,0.0001052515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978864,0.0005806896,0.0001864769,0.0001735406,0.0001235941,0.0001530034,0.00002775244,0.00003158916,0.00083691],"genre_scores_gemma":[0.9950976,0.00001133062,0.000264516,0.00003804172,0.000009962574,0.00002743294,0.00001678429,0.000005340275,0.004529034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02091645,"threshold_uncertainty_score":0.9998122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435682246986726,"score_gpt":0.2651085181725339,"score_spread":0.2507516957026666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}