{"id":"W3181911204","doi":"10.1002/jlb.2a1220-850rrr","title":"The Akt–mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial cell proliferation","year":2021,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Mesangial cell; mTORC1; Protein kinase B; PI3K/AKT/mTOR pathway; Biology; Cell biology; Cell growth; GAS6; AXL receptor tyrosine kinase; Receptor tyrosine kinase; Cancer research; Signal transduction; Endocrinology; Biochemistry; JAK-STAT signaling pathway; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007786421,0.0001972475,0.0004257532,0.0001005852,0.0003468811,0.00004079202,0.0002805834,0.0003916868,0.0002694514],"category_scores_gemma":[0.0004534103,0.0001252174,0.0002344508,0.0001742385,0.0001491901,0.0001580026,0.00007973989,0.0004572506,0.0001275081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332735,"about_ca_system_score_gemma":0.0004905971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009797242,"about_ca_topic_score_gemma":0.00001457878,"domain_scores_codex":[0.9978454,0.0007363635,0.000790051,0.000201435,0.00006310051,0.0003636751],"domain_scores_gemma":[0.9980494,0.0004368222,0.0007097717,0.0002523994,0.0005123246,0.00003921798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003439036,0.0001152182,0.0006901285,0.000006891427,0.0001384568,0.000006708107,0.0001743397,0.000003834951,0.9784239,0.0008421825,0.003960344,0.01529411],"study_design_scores_gemma":[0.001547731,0.0005567177,0.001570871,0.00002160228,0.00003984237,0.0001778586,0.000151599,0.000004988435,0.8311557,0.0002203232,0.1644287,0.0001240543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664239,0.02708086,0.0002160082,0.001631087,0.004083598,0.0001382729,0.00001314027,0.00001973512,0.0003933605],"genre_scores_gemma":[0.9964601,0.00130773,0.0001050257,0.0001636619,0.0005841418,0.000007067472,0.0001128768,0.00001769548,0.001241675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1604683,"threshold_uncertainty_score":0.5106218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566790465284714,"score_gpt":0.2458153827968511,"score_spread":0.230147478144004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}